drug holiday


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drug hol·i·day

(drŭg hol'i-dā),
Interval of time when a chronically medicated patient temporarily stops taking the medication; used to allow some recuperation of normal functions, to maintain sensitivity to the drug, and to reduce the likelihood of side-effects.

drug holiday

n.
A usually brief period during which a drug that is typically taken on a daily basis, such as an antidepressant, is not taken or is replaced with another in order to minimize certain side effects.

drug holiday

a period of drug withdrawal to reverse ineffectiveness of a drug resulting from receptor desensitization or adverse effects that may result from chronic treatment. For example, after a 7- to 10-day drug holiday, levodopa responsiveness appears to be enhanced, and lower doses are required to produce a therapeutic effect.
Therapeutics A time frame during which a drug is proscribed, to evaluate baseline behaviour or decreased the dose of psychoactive drugs, and possibly the incidence of tardive dyskinesia
Vox populi A trip to a place where some usually illicit drugs are legal—e.g., Amsterdam, Jamaica

drug holiday

Psychiatry A period in which a prescribed drug is proscribed, to evaluate baseline behavior or ↓ the dose of psychoactive drugs, and possibly incidence of tardive dyskinesia. See Tardive dyskinesia.

drug hol·i·day

(drŭg hol'i-dā)
Interval when a patient on long-term medication temporarily stops taking the prescribed medication; used to allow some recuperation of normal functions or to maintain sensitivity to the drug(s).

drug hol·i·day

(drŭg hol'i-dā)
Interval of time when a patient on long-term medication temporarily stops taking the medication; used to allow some recuperation of normal functions.
References in periodicals archive ?
Of the 38 patients in the control arm, 6 insisted upon discontinuing treatment so they could enter the drug holiday arm of the study.
For some patients who have been on daily bisphosphonates for years and who are tired of coordinating their lives around taking the drug on an empty stomach with plain water, a drug holiday lasting a few years probably is acceptable, the data suggest.
SALT LAKE CITY--The risk of permanent disability from a multiple sclerosis attack is extremely rare and does not appear to be tied to drug holidays, data on more than 1,000 MS patients showed.
Because of insufficient safety data in pregnant and breast-feeding women, prudence dictates a 1- to 2-year drug holiday in what is otherwise lifelong therapy.
If you can't find an alternative diagnosis, consider a short drug holiday and see what happens," he recommended.
SEATTLE -- Women who have been taking a bisphosphonate for a few years do not need a drug holiday, even though the drugs are retained in bone.
That's why the recommendation is that around the 5-year point you can consider having a drug holiday or switching off the bisphosphonates.
Background: The effects of vedolizumab retreatment after up to one year of drug holiday in UC patients who, after initial response, were re-randomized to placebo or lost response during GEMINI 1, were evaluated using an interim analysis (22 May 2009 -- 27 June 2013) of data from GEMINI LTS.
Following the recommendation of the project team's position paper published in Osteoporosis International in July 2012, the working group has started the Drug Holiday Study and the Common/Consistent Normative Reference Population Database Study, two of the five investigator-initiated studies called for by the 2012 bone turnover marker consortium.
The decision to prescribe bisphosphonates depends on several factors, including dual-energy x-ray absorptiometry (DXA) results and patient factors, and consideration for a drug holiday is warranted in each patient's care, Dr.
The researchers cautioned clinicians and patients contemplating a drug holiday after 5 years of treatment to "be aware that short-term monitoring to detect individuals at higher risk who might resume bisphosphonate therapy, or initiate another therapy, may not add to risk prediction over and above age and BMD measured at the time of discontinuation.
Pourhassan added that treatment substitution study has the potential to provide a drug holiday to patients from their daily pill regimen.