drug holiday


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drug hol·i·day

(drŭg hol'i-dā),
Interval of time when a chronically medicated patient temporarily stops taking the medication; used to allow some recuperation of normal functions, to maintain sensitivity to the drug, and to reduce the likelihood of side-effects.

drug holiday

n.
A usually brief period during which a drug that is typically taken on a daily basis, such as an antidepressant, is not taken or is replaced with another in order to minimize certain side effects.

drug holiday

a period of drug withdrawal to reverse ineffectiveness of a drug resulting from receptor desensitization or adverse effects that may result from chronic treatment. For example, after a 7- to 10-day drug holiday, levodopa responsiveness appears to be enhanced, and lower doses are required to produce a therapeutic effect.
Therapeutics A time frame during which a drug is proscribed, to evaluate baseline behaviour or decreased the dose of psychoactive drugs, and possibly the incidence of tardive dyskinesia
Vox populi A trip to a place where some usually illicit drugs are legal—e.g., Amsterdam, Jamaica

drug holiday

Psychiatry A period in which a prescribed drug is proscribed, to evaluate baseline behavior or ↓ the dose of psychoactive drugs, and possibly incidence of tardive dyskinesia. See Tardive dyskinesia.

drug hol·i·day

(drŭg hol'i-dā)
Interval when a patient on long-term medication temporarily stops taking the prescribed medication; used to allow some recuperation of normal functions or to maintain sensitivity to the drug(s).

drug hol·i·day

(drŭg hol'i-dā)
Interval of time when a patient on long-term medication temporarily stops taking the medication; used to allow some recuperation of normal functions.
References in periodicals archive ?
In this study a questionnaire was filled up by oncologists so as to assess their thoughts about the positive and adverse effects of bisphosphonates, drug holiday and the awareness of the potential risks regarding the patients under bisphosphonates therapy.
Other scenarios in which an endocrinologist can help involve patients with bisphosphonate toxicity, or patients who have taken a bisphosphonate for a number of years and may be a candidate for a drug holiday.
Key clinical point: This MEK inhibitor-associated cutaneous eruption can be treated with a drug holiday and oral corticosteroid treatment, restarting the drug at a lower dose without recurrence.
In those patients who warrant therapy, the duration of therapy and a drug holiday should also be considered because of the concern for potential risks associated with prolonged bisphosphonate therapy, she said.
Studies have found adaptation rates generally are low (~10%) Pharmacologic Drug holiday May be an option for patients taking antidepressants with shorter half-lives and patients taking lower doses.
In a season that proved a disappointment across retail trade channels, consumers mustered very little enthusiasm for the basic chain drug holiday assortment, one that had proven adequate in the past.
If you've been taking bisphosphonates for over five years, talk with your clinician about stopping altogether or taking a drug holiday.
The efficacy of a drug holiday for patients receiving yearly zoledronic acid therapy and the appropriate timing of dentoalveolar surgery (if required) are unknown and therefore require further study.
In the beginning of his daily propofol consumption he remembered a voluntary drug holiday lasting two weeks which was associated with mild anxiety, lack of concentration, increasing sleeplessness and a strong desire for propofol before relapsing.
Antibodies to infliximab are much more likely to develop in response to episodic treatment and in patients who have had a prolonged drug holiday between courses.
Ideally, the decision to take a drug holiday will be made jointly by the family and the physician, with appropriate input from the camp staff and the child, well in advance of the camp session.
The drug holiday included 40 residents who gave consent, regardless of the dosage of haloperidol they were receiving or their diagnoses for indication.