drug concentration

0.03 sec.

drug concentration,

the amount of drug in a given volume of plasma (e.g., number of micrograms per milliliter). Toxic drug levels may be observed when the body's normal mechanisms for metabolizing and excreting drugs are impaired, as commonly occurs in patients with liver or kidney disorders and in infants with immature organs. Dosage adjustments should be made in such individuals to accommodate their impaired metabolism and excretion.

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? References in periodicals archive

Proper interpretation of therapeutic drug concentrations requires that the specimen be drawn at an appropriate time in relation to drug administration.

Critical values for therapeutic drug levels by Medical Laboratory Observer

Pharmacokinetic-pharmacodynamic modeling is able to mathematically describe this hysteresis and fully explain how the same blood drug concentration can produce variable effects.

The pharmacokinetics and pharmacodynamics of thiopental as used in ... by Dershwitz, Mark; Henthorn, Thomas K. / Fordham Urban Law Journal

High interpatient variability has been reported, but this value showed initial adequate drug concentration and excluded impaired bioavailability (13).

Plasmodium falciparum malaria and atovaquone-proguanil treatment ... by Durand, Remy; Prendki, Virginie; Cailhol, Johann; Hubert, Veronique; Ralaimazava, Pascal; Massias, L / Emerging Infectious Diseases

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