drug concentration

drug concentration

the amount of drug in a given volume of plasma (e.g., number of micrograms per milliliter). Toxic drug levels may be observed when the body's normal mechanisms for metabolizing and excreting drugs are impaired, as commonly occurs in patients with liver or kidney disorders and in infants with immature organs. Dosage adjustments should be made in such individuals to accommodate their impaired metabolism and excretion.
References in periodicals archive ?
The extraction procedure was simple with good response even at very low drug concentration, thereby making this method suitable for pharmacokinetic application.
They enable the visualization of drug delivery and distribution, and potentially permit the quantification of local drug concentration with subcellular resolution.
Kraujalis addressed the problem of drug delivery and distribution of drug concentration among various compartments using timed automata.
Overall, ADAs are associated with low trough drug concentration, reduced clinical response, or remission of clinical disease and increased incidence of infusion or injection-site reactions (39, 40).
The peak heights obtained at different concentrations of the drug were plotted against the drug concentration.
TCI relies on population-based pharmacokinetics (PK) and pharmacodynamics (PD) models for calculating a proper infusion profile to achieve the reference drug concentration set by the anesthesiologist [5].
Serum drug concentration versus time curves best fit a 2-compartment model in those trials (n = 7) for which concentrations were sufficiently detectable to allow modeling (Figs 1 and 2).
It was reported that cefazedone sodium presents high serum protein binding rate (93-96%), therefore, the free drug concentration in the blood plasma would be 4-7% of the actual measurement.
The PC1 will be used to monitor blood concentration, oxygen saturation, and drug concentration during surgical procedures.
Further increasing in drug concentration in B, C and D formulations the entrapment efficiency was significantly (P<0.
Neupro Patch is the only transdermal dopamine agonist system available in the world, which only needs to be applied once a day, enabling a clinically-effective blood drug concentration via stable drug delivery throughout a 24-hour period.
With the help of our simulation, we can now tell with a fair degree of certainty what level of viral suppression is being achieved - how hard it is for the virus to grow and replicate - for a particular drug combination, at a specific dosage and drug concentration in the blood, even when a dose is missed," said Siliciano, a professor at the Johns Hopkins University School of Medicine and a Howard Hughes Medical Institute investigator.