drug concentration

drug concentration

the amount of drug in a given volume of plasma (e.g., number of micrograms per milliliter). Toxic drug levels may be observed when the body's normal mechanisms for metabolizing and excreting drugs are impaired, as commonly occurs in patients with liver or kidney disorders and in infants with immature organs. Dosage adjustments should be made in such individuals to accommodate their impaired metabolism and excretion.
References in periodicals archive ?
The PC1 will be used to monitor blood concentration, oxygen saturation, and drug concentration during surgical procedures.
Further increasing in drug concentration in B, C and D formulations the entrapment efficiency was significantly (P<0.
An assessment of the in-vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose.
Neupro Patch is the only transdermal dopamine agonist system available in the world, which only needs to be applied once a day, enabling a clinically-effective blood drug concentration via stable drug delivery throughout a 24-hour period.
A non-inferiority endpoint was chosen to ensure that patients are not under-dosed as compared to the established IV dose and treatment intervals, and the study met its primary endpoint by confirming that the minimum drug concentration during a given dosing interval (Ctrough) was non-inferior for MabThera SC vs.
With the help of our simulation, we can now tell with a fair degree of certainty what level of viral suppression is being achieved - how hard it is for the virus to grow and replicate - for a particular drug combination, at a specific dosage and drug concentration in the blood, even when a dose is missed," said Siliciano, a professor at the Johns Hopkins University School of Medicine and a Howard Hughes Medical Institute investigator.
Many consumers also have a wrong perception that any product marketed as herbal is safe, in many cases we have gathered and tested these products and found it to contain undefined chemicals or unknown drug concentration leading to a risk to the health of the user', Al Ali added.
Zysolin improves the intracellular activity of Tobramycin - in layman's term, increasing the drug concentration of Tobramycin inside human macrophages, thus improving its antibacterial activity against intracellular Klebsiella, Pseudomondas aeruginosa and Staphylococcus bacterial strains in pneumonia patients.
To describe the diffusional transport of the drug the following premises were used: at the surface of the dosage the drug concentration is constant; the release of the drug follows a first order kinetics (the release rate is proportional to its concentration); diffusion is isotropic (it does not depend on the spatial direction); the convective process is insignificant, thus it can be neglected; the release of the drug from the cylinders occurs only in axial direction (Siepmann et al.
That corresponds to a trough plasma drug concentration of 50 ng/mL or more.
Decreasing the maternal plasma drug concentration will decrease concentration in the milk and consequently the infant's dose.