drug clearance

drug clearance

the elimination of a drug from the body. Drugs and their metabolites are excreted primarily by the kidneys into the urine, but other routes for elimination include bile, sweat, saliva, breast milk, and expired air. The rate of clearance helps determine the size and frequency of a dosage of a particular medication.
References in periodicals archive ?
DCR began in 1985 as a pharmacology unit within an academic hospital, conducting drug clearance and pharmacokinetic studies.
The survey used 12 statements based on key pharmacological principles identified from literature: rationale, application, mechanism of action, monitoring, drug clearance, dosing, formulation, adverse effects, predictable side effects, client education, drug information and evaluation.
ANSTO s Arvind Parmer and his colleagues have used the radiopharmaceutical technetium (99mTc) sestamibi, which acts as a marker, to investigate drug clearance and toxicity.
Tokyo JPN), the maker of the Alzheimer's disease treatment Aricept, won approval to sell a therapy for breast cancer, marking the company's first original drug clearance in the U.
Such interactions can thereby lead to delayed drug clearance.
Drug clearance is predicted in vitro using rat and human microsomal stability assays, but the Metasite tool is plugged into ESMA and allows chemists to quickly assess likely metabolic weak points on their molecules, which they should seek to address.
Due to the identified slow drug clearance, anaesthesia was maintained with either propofol or isoflurane for follow-up laparotomies.
A geriatric pharmacokinetic database was developed to analyze changes in drug clearance with advancing age.
One other mutation, found almost exclusively in blacks, was also associated with slower drug clearance.
Third and finally, the present system of drug test fines is unjust, immoral and antediluvian and needs urgent review to allow for split samples, guidance on drug clearance times, fines reflecting the seriousness of the offences (less for beta-blockers than a veterinary prescribed anti-inflammatory in one case) and the right of appeal.
The Phase 1b clinical trial represented the first time NEUGENES had been given to adult patients with substantial impairment of kidney function, which is important for drug clearance and metabolism.
The effect of illness on drug clearance also must be considered.