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drug clearance

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drug clearance,
the elimination of a drug from the body. Drugs and their metabolites are excreted primarily by the kidneys into the urine, but other routes for elimination include bile, sweat, saliva, breast milk, and expired air. The rate of clearance helps determine the size and frequency of a dosage of a particular medication.


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It is known, however, that more rapid drug clearance occurs in pediatric patients when compared to adults.
2) This is especially true where the offending drug causes dose-related toxicity, and thus overall exposure depends on drug clearance.
Drug clearance and drug half-life is altering with renal excreted medications and hepatic metabolized medications.
 
 
 
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