drug clearance

drug clearance

the elimination of a drug from the body. Drugs and their metabolites are excreted primarily by the kidneys into the urine, but other routes for elimination include bile, sweat, saliva, breast milk, and expired air. The rate of clearance helps determine the size and frequency of a dosage of a particular medication.
References in periodicals archive ?
The National Institutes of Health estimate that 275,000 patients in the United States undergo 5-FU therapy annually and that 1,300 die of 5-FU overexposure, which can result from either overdoses or poor drug clearance.
With drug clearance varying by as much as 30-fold among different individuals, the traditional Body Surface Area (BSA) dosing methods result drug concentrations in the blood that vary widely.
The finding that the methylphenidate-induced improvements in sleep persisted for a week after drug clearance is consistent with brain imaging studies carried out by Dr.
Contract awarded for Convention No Prescription Drug Clearance Cenabast
Pharmacokinetic models that are used for Bayesian analysis in therapeutic drug monitoring include an index of renal function such as CrCl to describe drug clearance.
The survey used 12 statements based on key pharmacological principles identified from literature: rationale, application, mechanism of action, monitoring, drug clearance, dosing, formulation, adverse effects, predictable side effects, client education, drug information and evaluation.
This particular kidney cell type plays an important role in kidney disease-related processes and drug clearance.
The clinical study is open for enrollment having received Investigational New Drug clearance from the FDA and Investigational Review Board clearance from Duke University Medical Center(clinicaltrials.
However, plasmapheresis (PP)--separation of plasma and cellular components of blood--can increase drug clearance, which may affect how you manage patients who donate plasma frequently.
Tokyo JPN), the maker of the Alzheimer's disease treatment Aricept, won approval to sell a therapy for breast cancer, marking the company's first original drug clearance in the U.