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drug clearance |
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drug clearance, the elimination of a drug from the body. Drugs and their metabolites are excreted primarily by the kidneys into the urine, but other routes for elimination include bile, sweat, saliva, breast milk, and expired air. The rate of clearance helps determine the size and frequency of a dosage of a particular medication. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Drug clearance and drug half-life is altering with renal excreted medications and hepatic metabolized medications. Through a series of simulated application scenarios, Plontke and Salt demonstrated that controlling middle ear drug clearance is of critical importance when administering the drugs to the inner ear. Reductions in scrum proteins, especially albumin, and an expanded volume of distribution may hasten drug clearance so long as excretory-renal and/or hepatic-function remains intact (5). |
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