The National Institutes of Health estimate that 275,000 patients in the United States undergo 5-FU therapy annually and that 1,300 die of 5-FU overexposure, which can result from either overdoses or poor drug clearance
With drug clearance
varying by as much as 30-fold among different individuals, the traditional Body Surface Area (BSA) dosing methods result drug concentrations in the blood that vary widely.
The finding that the methylphenidate-induced improvements in sleep persisted for a week after drug clearance
is consistent with brain imaging studies carried out by Dr.
Liver disease may have complex effects on drug clearance
, biotransformation, and pharmacokinetics.
Contract awarded for Convention No Prescription Drug Clearance
Pharmacokinetic models that are used for Bayesian analysis in therapeutic drug monitoring include an index of renal function such as CrCl to describe drug clearance
The survey used 12 statements based on key pharmacological principles identified from literature: rationale, application, mechanism of action, monitoring, drug clearance
, dosing, formulation, adverse effects, predictable side effects, client education, drug information and evaluation.
However, this dose may not be a perfect "one size fits all" when considering drug clearance
, side effects, and other factors.
This particular kidney cell type plays an important role in kidney disease-related processes and drug clearance
The clinical study is open for enrollment having received Investigational New Drug clearance
from the FDA and Investigational Review Board clearance from Duke University Medical Center(clinicaltrials.
However, plasmapheresis (PP)--separation of plasma and cellular components of blood--can increase drug clearance
, which may affect how you manage patients who donate plasma frequently.
Tokyo JPN), the maker of the Alzheimer's disease treatment Aricept, won approval to sell a therapy for breast cancer, marking the company's first original drug clearance
in the U.