doxylamine


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doxylamine

 [dok″sil-am´ēn]
an antihistamine with sedative and anticholinergic effects; used as the succinate salt in the treatment of nasal, eye, and skin manifestations of allergic reactions, including allergic rhinitis, conjunctivitis, and itching, as an ingredient in cough and cold preparations, and in the short-term treatment of insomnia, administered orally.

doxylamine/pyridoxine

(dox-il-a-meen peer-ih-dox-een ),

Diclegis

(trade name),

Diclectin

(trade name)

Classification

Therapeutic: antiemetics
Pharmacologic: antihistamines
Pregnancy Category: A

Indications

Treatment of nausea and vomiting during pregnancy that has not responded to conservative management.

Action

Combination of an antihistamine and a vitamin B6 analog. Mechanism not known.

Therapeutic effects

Decreased nausea and vomiting associated with pregnancy.

Pharmacokinetics

Absorption: Well absorbed following oral administration. Food delays/decreases absorption.
Distribution: Doxylamine probably enters breast milk
Metabolism and Excretion: Doxylamine is mostly metabolized by the liver, inactive metabolites are renally excreted. Pyridoxine is a pro-drug, converted to its active metabolite by the liver.
Half-life: Doxylamine—12.5 hr; pyridoxine—0.4–0.5 hr

Time/action profile (anti-emetic effect)

ROUTEONSETPEAKDURATION
POunkunk8–24 hr

Contraindications/Precautions

Contraindicated in: Hypersensitivity to doxylamine or pyridoxineConcurrent use of MAOIs Lactation: Doxylamine probably enters breast milk and may cause irritability, excitement, or sedation in infants; breast feeding should be avoided.
Use Cautiously in: AsthmaIncreased intraocular pressure or narrow angle glaucomaStenosing peptic ulcer or pyloroduodenal obstructionUrinary bladder-neck obstruction Pediatric: Safe and effective use in children <18 yr has not been established

Adverse Reactions/Side Effects

Central nervous system

  • drowsiness (most frequent)

Interactions

Drug-Drug interaction

↑ risk of CNS depression with other CNS depressants including alcohol, other antihistamines, opioid analgesics, and sedative/hypnotics Concurrent use of MAOIs ↑ intensity/duration of adverse CNS (anticholinergic) reactions

Route/Dosage

Oral (Adults) Day 1—Two tablets (doxylamine 10 mg/pyridoxine 10 mg) at bedtime, if symptoms are controlled continue this regimen; Day 2, if symptoms persist into afternoon on day 2—two tablets at bedtime on day 2 and then one tablet in the morning on day 3 and two tablets in the evening, if symptoms are controlled, continue this regimen; Day 4, if symptoms persist—one tablet in the morning, one tablet mid-afternoon and two tablets at bedtime (not to exceed four tablets daily).

Availability

Delayed-release tablets: doxylamine 10 mg/pyridoxine 10 mg

Nursing implications

Nursing assessment

  • Assess for frequency and amount of emesis daily during therapy. Reassess need for medication as pregnancy progresses.

Potential Nursing Diagnoses

Nausea (Indications)
Risk for injury (Adverse Reactions)

Implementation

  • Oral: Administer on an empty stomach with a full glass of water; food delays onset of medication. Swallow tablets whole; do not crush, break, or chew.

Patient/Family Teaching

  • Instruct patient to take as directed.
  • May cause drowsiness. Caution patient to avoid driving and other activities requiring alertness until response to medication is known.
  • Advise patient to avoid alcohol and CNS depressants, including sedatives, tranquilizers, antihistamines, opioids, and some cough and cold medications with doxylamine pyridoxine.
  • Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
  • Advise female patient to avoid breast feeding during therapy.

Evaluation/Desired Outcomes

  • Decrease in frequency of nausea and vomiting during pregnancy.

doxylamine

/dox·yl·amine/ (dok-sil´ah-mēn) an antihistamine with anticholinergic and sedative effects, used as the succinate salt.

doxylamine

an antihistamine used in the treatment of allergic reactions and laminitis in cattle and horses.
References in periodicals archive ?
We present three cases in which ingestion of large amounts of diphenhydramine or doxylamine was associated with impressive rhabdomyolysis.
Doxylamine succinate is a muscle relaxant, adding to the feeling of relaxation which codeine provides.
Fatalities have been reported from doxylamine overdose in children.
The delayed release combination of 10 mg doxylamine and 10 mg pyridoxine (Diclectin[sup.
In contrast, doxylamine and cetirizine appeared to do nothing to the tumors in these rodents.
Some false-positive results for methadone have already been reported with other techniques and were attributable to metabolites of verapamil (4), diphenhydramine (5), or doxylamine (6).
What would make sense now is to compare the safety and effectiveness of ginger and drugs, such as ondansetron and doxylamine and vitamin [B.
Sneezing and runny noses - antihistamines such as chlorpheniramine and doxylamine can help to relieve the symptoms of sneezing and runny noses as they help to dry up secretions and also have a sedative action.
5 MG, ZOLPIDEM TAB 5 MG, CINNARIZINE TAB 25 MG, DOXYLAMINE 10 MG+PYRIDOXIN 10 MG TAB, PHENYTOIN SODIUM 100 MG TAB, CARBAMAZEPINE CR 200 MG TAB etc
Until the early 1980s, the combination of the antihistamine doxylamine succinate and the vitamin [B.
The antihistaminergic sleep aids diphenhydramine and doxylamine had relatively high affinity for the H1 site, but bound to muscarinic sites as well.
The FDA announced the approval of a delayed-release, fixed-dose formulation of 10 mg of doxylamine, an antihistamine; and 10 mg of pyridoxine, a vitamin 86 analog, for "the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management.