doxorubicin


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Related to doxorubicin: cyclophosphamide, Doxorubicin hydrochloride, liposomal doxorubicin

doxorubicin

 [dok″so-roo´bĭ-sin]
an antitumor antibiotic that binds to DNA, inhibits synthesis of nucleic acids, and inhibits cell division. It has one of the widest spectrums of antitumor activity of any antineoplastic agent and is administered intravenously as the hydrochloride salt. Side effects include bone marrow depression, alopecia, and cardiac toxicity; electroencephalogram monitoring is required during its administration. A liposome-encapsulated preparation of the hydrochloride salt is used in the treatment of Kaposi's sarcoma associated with acquired immunodeficiency syndrome (AIDS).

dox·o·ru·bi·cin

(doks'ō-rū'bi-sin),
An antineoplastic antibiotic isolated from Streptomyces peucetius; also used in cytogenetics to produce Q-type chromosome bands.
Synonym(s): adriamycin

doxorubicin

/doxo·ru·bi·cin/ (dok″so-roo´bĭ-sin) an antineoplastic antibiotic, produced by Streptomyces peucetius, which binds to DNA and inhibits nucleic acid synthesis; used as the hydrochloride salt and as a liposome-encased preparation of the hydrochloride salt.

doxorubicin

(dŏk′sə-ro͞o′bĭ-sĭn)
n.
An antibiotic obtained from the bacterium Streptomyces peuceticus, used as an anticancer drug.

ABDIC

A "salvage" chemotherapy regimen used for patients who have a disease—e.g., lymphoma—relapse after radiation therapy or chemotherapy.

doxorubicin

Adriamycin Oncology An anthracycline antibiotic used for leukemias, lymphomas, sarcomas, solid tumors Adverse effects BM suppression, alopecia, vomiting, stomatitis, dose-dependent cardiomyopathy. See Chemotherapy.

dox·o·ru·bi·cin

(doks'ō-rū'bi-sin)
An antineoplastic antibiotic isolated from Streptomyces peucetius; also used in cytogenetics to produce Q-type chromosome bands.
Synonym(s): adriamycin.

doxorubicin

An antibiotic, also known as Adriamycin, that interferes with the synthesis of DNA and is thus useful an an anticancer agent. It has many side effects including loss of hair, sickness and vomiting, interference with blood production and heart damage. The drug is on the WHO official list. A brand name is Caelyx.

doxorubicin

an antineoplastic antibiotic, which binds to DNA and inhibits synthesis of nucleic acids and cell division. It is used intravenously to produce regression in various neoplastic conditions. The side-effects include bone marrow depression, alopecia and cardiac toxicity. Called also adriamycin. See also anthracycline antibiotic.
References in periodicals archive ?
Small area of tumor cells in doxorubicin group from MCF-7/DOX xenograft showed cytoplasm vacuolization and nuclei degeneration.
Even in this age of targeted therapies, doxorubicin remains an effective agent used mainly in combination with other drugs against a variety of malignancies, including breast, lung, ovarian and bladder cancers, as well as leukemia and lymphoma," said Edward T.
A recently initiated phase III randomized trial of the effectiveness of sorafenib with or without doxorubicin in patients with advanced HCC is presently under way.
There was concern that dexrazoxane might attenuate some of the antitumor effect of the doxorubicin if it was started from the get-go as opposed to starting it later.
Each doxorubicin dose was infused with 150 cc of 5% dextrose over 30 minutes for all patients enrolled in the study.
6 months for patients on doxorubicin alone, a 51% improvement
In the new study, reported in the November NATURE MEDICINE, the tumors in 50 mice shrank slightly over 11 weeks following treatment with conventional doxorubicin.
Introduction of the anthracycline drug doxorubicin in the 1970s represented a major advance in cancer therapy.
With respect to possible doxorubicin cardiac toxicity, our patient had no clinical evidence of cardiomyopathy.
The trial compared the antitumor efficacy and tolerability of weekly intravenous treatments with saline or doxorubicin compared with three dosing regimens of either aldoxorubicin alone or combination aldoxorubicin and doxorubicin in a xenograft model of human pancreatic cancer.
Director of the Sarcoma Oncology Center and principal investigator for this trial stated, "The use of doxorubicin with ifosfamide and mesna remains a treatment option for many sarcoma patients.