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doxorubicin |
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doxorubicin /doxo·ru·bi·cin/ (dok?so-roo´bi-sin) an antineoplastic antibiotic, produced by Streptomyces peucetius, which binds to DNA and inhibits nucleic acid synthesis; used as the hydrochloride salt and as a liposome-encased preparation of the hydrochloride salt.
doxorubicin an antineoplastic antibiotic, which binds to DNA and inhibits synthesis of nucleic acids and cell division. It is used intravenously to produce regression in various neoplastic conditions. The side-effects include bone marrow depression, alopecia and cardiac toxicity. Called also adriamycin. See also anthracycline antibiotic. |
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Bert Vogelstein and his colleagues at the Johns Hopkins cancer center in Baltimore injected mice with microscopic containers, called liposomes, loaded with the anti-cancer drag doxorubicin. Super-Leu-Dox consists of doxorubicin (a marketed cytotoxic compound used in treating cancer) conjugated to a proprietary prodrug peptide. In the reported study, doxorubicin and a MRI contrast agent were encapsulated in Celsion's heat activated liposome. |
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doxorubicin
