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doxercalciferol

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doxercalciferol /dox·er·cal·cif·er·ol/ (dok″ser-kal-sif´er-ol) a synthetic analogue of vitamin D, used to reduce levels of circulating parathyroid hormone in the treatment of secondary hyperparathyroidism associated with chronic renal failure.
doxercalciferol,
a parathyroid agent (calcium regulator).
indications It is used to lower high parathyroid hormone levels in patients undergoing chronic kidney dialysis.
contraindications Known hypersensitivity to this drug, hyperphosphatemia, hypercalcemia, and vitamin D toxicity prohibit its use.
adverse effects Adverse effects include drowsiness, headache, lethargy, nausea, diarrhea, vomiting, anorexia, dry mouth, constipation, cramps, metallic taste, myalgia, arthralgia, decreased bone development, polyuria, hypercalciuria, hyperphosphatemia, hematuria, and shortness of breath.
doxercalciferol [dok″ser-kal-sif´er-ol]
a synthetic analogue of vitamin D2, used to reduce levels of circulating parathyroid hormone in treatment of secondary hyperparathyroidism associated with chronic renal failure; administered orally or intravenously.
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Pharmaceutical drug forms of activated vitamin D include calcitriol, doxercalciferol, and calcipotriene.
Guarding against the dangers of vitamin D deficiency by Johnson, Tiesha D. / Life Extension
According to the 483, a validation report for Akorn's production of Hectorol (doxercal-ciferol) for injection stated that all batches met acceptance criteria with regard to doxercalciferol potency during filtration and filling with the exception of an end-of-filtrate sample in one lot, despite an entry in the lab notebook indicating greater-than-specified potency for doxercalciferol.
Akorn digs out from under 21-page EIR, warning letter by Inspection Monitor
 
 
 
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