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Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism," American Journal of Physiology: Renal Physiology, vol.
Pharmaceutical company Akorn (NasdaqGS:AKRX) stated on Monday that it has introduced Doxercalciferol Injection Solution, 4 mcg/2 ml in 2ml single-use vials in the market.
This launch follows an approval of an abbreviated new drug application for Doxercalciferol Injection Solution, 4 mcg/2 ml in 2ml single-use vials from the US Food and Drug Administration on 7 May 2015.
Pharmaceutical drug forms of activated vitamin D include calcitriol, doxercalciferol, and calcipotriene.
5% Lupin Dexmethylphenidate Hydrochloride Mylan Extended-Release Capsules, 30 mg Adefovir Dipivoxil Tablets, 10 mg Sigmapharm Adenosine Injection USP, 3 mg/ml, Teva packaged in 60 mg/20 ml and 90 mg/30 ml single-dose vials Lansoprazole Delayed-Release Capsules Teva USP, Amoxicillin Capsules USP and Clarithromycin Tablets USP, 30 mg/500 mg/500 mg Doxercalciferol Injection, 2 mcg/mi, Innopharma pack-aged in 4 mcg/2 ml single-use ampules SEPTEMBER 2013 Bivalrudin for Injection, 250 mg/vial, Hospira packaged in single-use flip-top vials Azacitidine for Injection, 100 mg, packaged Dr.
Doxercalciferol is not indicated in ESLD as sufficient hepatic mass may not be present to complete the conversion to calcitriol.
The fact that calcitriol increases levels of calcium and phosphorus, which has been associated with increased morbidity and mortality in dialysis patients, led to the development of two second-generation vitamin D sterols, paricalcitol and doxercalciferol.
Predialysis patients (and peritoneal dialysis and home hemodialysis patients) can benefit from the convenience of an oral formulation of doxercalciferol (Hectorol[R]) (Maung et al.
Efficacy and side effects of intermittent intravenous and oral doxercalciferol (1-hyrdoxyvitamin D) in dialysis patients with secondary hyperparathyroidism: A sequential comparison.
There are currently four Vitamin D products on the market that do not require activation by the kidney: calcitriol injection (Calcijex[R], Abbott), paricalcitol injection (Zemplar[R], Abbott), oral calcitriol (Rocaltrol[R], Roche), and oral doxercalciferol (Hectorol[TM]).
One of these analogs, doxercalciferol (Hectorol), was recently approved by the Food and Drug Administration (FDA).