downstaging

downstaging

(down'staj?ing)
Decreasing the size, extent of metastases, and/or lymph node involvement of a tumor by means of anticancer therapy.
Synonym: downsizing See: debulking
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Neoadjuvant chemotherapy in small cell urothelial cancer improves pathologic downstaging and long-term outcomes: Results from a retrospective study at the MD Anderson Cancer Center.
safe and effective with superior surgical downstaging.
SNFs are required to report healing pressure ulcers in a sequence of "downstages," but there is no scientific rationale for downstaging.
By upstaging or downstaging disease, this hybrid imaging tool may alter the management of more than one-third of patients with the disease," said Dr.
Of the 16 patients undergoing neoadjuvant therapy who had complete pathologic response or significant downstaging from stage III disease, Kaplan-Meier 5-year survival was 61% ([+ or -] 15).
The National Pressure Ulcer Advisory Panel (NPUAP) has taken the position that once an ulcer has reached an advanced stage, that ulcer should not be "downstaged" as it heals; NPUAP says that in the ulcer documentation, this lesion should be referred to as a "healing stage IV" rather than downstaging to stages III, II, or I.
While it may have a role in downstaging--several studies showed a 30% to 40% downstaging success rate--it has increased morbidity rates both intraoperatively and postoperatively and causes patient dropout from protocol due to the toxicities of the therapy.
A secondary objective was to compare the pT0 and tumour downstaging rates in patients who received radical cystectomy alone against those who received cispatin and gemcitabine (CG) neoadjuvant chemotherapy and radical cystectomy.
Downstaging is associated not only with a better prognosis, but also with a better chance at sphincter preservation during surgery, Dr.
In 13/30 of the patients non-surgical treatment was continued, eventually achieving a total response in all patients of 23/30 (77%), 14 resectable cases with downstaging and 9 partial remissions after hyperthermic radiochemotherapy.
From a reimbursement standpoint, the use of reverse or downstaging in long-term care stems from wound care coverage criteria - the providers' use of the resident assessment instrument (RAI) for clinical protocol.