downregulate


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Related to downregulate: Upregulate

downregulate

(down-rĕg′ū-lāt″)
To inhibit or suppress the normal response of an organ or system (e.g., the immune system or the central nervous system).
References in periodicals archive ?
300 mg/L of rhynchophylline was added to the medium to downregulate the level of EphA4.
Mounting evidence suggests that estrogen (E2) downregulates hepcidin synthesis and increases serum iron concentration.
The finding that heavy almost-daily cannabis use downregulates levels of FAAH after overnight cessation from cannabis use may explain the relative absence of withdrawal symptoms in very early abstinence, says Boileau, and suggests that strategies aimed at keeping levels of this enzyme down might help reduce cannabis withdrawal symptoms.
To determine which regions of MARCH4 are required to downregulate the surface expression of MHC I, truncated forms of MARCH4 were created.
Hormones rarely display dose linearity, and in some cases, high doses downregulate responses triggered by lesser exposures--in other words, different effects can appear and disappear at different doses.
MicroRNA 150 has been shown to downregulate the expression of C-MYB, a transcription factor that plays a significant role in megakaryopoiesis.
The kidneys perceive the pressure in the vessel and up- or downregulate the amounts of these hormones, which determines the "tone" of the vessel or the outside pressure.
65] or other proteins) stands out as potentially inducing long-term tolerance by induction of regulatory T cells that downregulate immunity to autoantigens.
But the mitogen-activated protein (MAP) kinase pathway, which mediates vasoconstriction, is driven by high levels of insulin and does not downregulate with insulin resistance.
Release of these genetic stocks makes brown midrib genes known to downregulate two specific enzymes important in lignin synthesis, cinnamyl alcohol dehydrogenase (bmr-6) and O-methyltransferase (bmr-12), available in diverse near-isogenic forage sorghum backgrounds allowing direct comparison of gene effects across these broad backgrounds.
4) KSHV evades immune responses in part through its intrinsic ability to downregulate major histocompatibility complex (MHC)-1 surface molecules, an effect that may be decreased it T-helper depletion is prevented or restored with HAART.
Therefore, wine consumption may downregulate the immune response that leads to colds.