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Mechanistically, [delta]T3 appears to downregulate the expression of tyrosinase, TYRP-1, and TYRP-2, which could be mediated by the suppression of transcription factors such as MITF.
Hormones rarely display dose linearity, and in some cases, high doses downregulate responses triggered by lesser exposures--in other words, different effects can appear and disappear at different doses.
Among these, miRNAs 32 and 17~92 cluster were specific for myeloma patients and the latter was shown to downregulate expression of SOCS-1, which inhibits interleukin 6 signaling.
1) Each of these five involved from 14 to 18 different agents or classes of agents that are predicted to downregulate one or more aspects of the NO/ONOO--cycle.
IK is hypothesized to engage the VPAC1 promoter upon activation and downregulate expression.
Additionally, they can downregulate allergic and asthmatic responses.
The primary aim of such therapies should be to downregulate inflammation locally in atherosclerotic plaques, thereby allowing repair processes to stabilize lesions.
But the mitogen-activated protein (MAP) kinase pathway, which mediates vasoconstriction, is driven by high levels of insulin and thus, does not downregulate with insulin resistance.
Downregulate fatty acid and cholesterol biosynthesis (16)
Our findings that TET can downregulate the expression of PA28gamma (Fig.
Genetic studies have begun to reveal genes that predispose a person to an inability to downregulate gut inflammation, such as the NOD2/cardl5 gene, located at chromosome 16ql2.
Romero answered that the obstetrician managing the patient with a fetal inflammatory response syndrome (FIRS) has three choices: immediate delivery to remove the fetus from the inflammatory environment; antibiotic treatment with the hope of prolonging pregnancy and reducing the rate of complications as was observed in randomized clinical trials of preterm PROM; and administering agents to downregulate the fetal inflammatory response.
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