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down-regulation |
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down-regulation /down-reg·u·la·tion/ (doun reg-u-la´shun) a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent. |
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First, the receptor typically undergoes down-regulation in the presence of excess acetylcholine, thus providing a time-integrated index of the degree of cholinergic hyperstimulation experienced by the developing brain after organophosphate exposure (Bushnell et al. Preliminary results from three Phase 1 clinical trials show that OGX-011 is well tolerated, achieves excellent drug concentrations in prostate tissue, and produces a 91 percent dose-dependent down-regulation of clusterin in prostate cancer cells removed from prostate cancer patients. Therefore, hyper-mutability in some strains of this species resulting in multiple rpoB mutants might develop under certain special (in vivo) circumstances through inactivation or down-regulation of some mutt genes. |
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down-regulation
