down-regulation


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Related to down-regulation: Upregulation, Up-regulation

down-regulation

 [down-reg-u-la´shun]
a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent. See also up-regulation.

down-reg·u·la·tion

(down-reg'yū-lā'shŭn),
Development of a refractory or tolerant state consequent on repeated administration of a pharmacologically or physiologically active substance; often accompanied by an initial decrease in affinity of receptors for the agent and a subsequent diminution in the number of receptors.

down-regulation

/down-reg·u·la·tion/ (doun reg-u-la´shun) a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent.

down-regulation

[doun reg-u-la′shun]
a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually caused by long-term exposure to the agent. See also up-regulation.
References in periodicals archive ?
Down-regulation of bovine NANOG was detected by both fluorescence microscopy (Figure 2A) and western blot analysis (Figure 2D).
Fucoxanthin, derived from brown seaweeds, has shown anti-adipose capability through modulating the elevation of ROS, and down-regulation of lipid metabolism genes.
Whereas the correlation between the down-regulation of TAP and increased tumourigenesis had been widely established the research of Dr Wilfred Jeffries and colleagues at the University of British Columbia, Vancouver BC provided the first critical demonstration that TAP1 gene transfer into tumour cells and cancer bearing animals could significantly improve the immune recognition of tumour-associated antigens.
Low free L-carnitine levels have been shown to result in a 2- to 3-fold down-regulation of the expression of carnitine acyltrans-ferases, the enzymes involved in fatty acid oxidation in the mitochondria.
It looks like in breast cancer cells, down-regulation of MARRS has a positive therapeutic benefit when using vitamin D strategies," [says Kelly Meckling who led the research.
We demonstrated a clear down-regulation of 3H-dexamethasone binding in ventilated patients.
They discuss transformation methods, the design of transgenes, uses of transgenic maize in research, expression of reporter genes, down-regulation of gene activity, gene isolation, different technologies, the analysis of plants, and experiments and breeding with transgenes, with laboratory protocols, materials, and notes on troubleshooting and pitfalls.
It is not due to receptor down-regulation or up-regulation.
Artemis will use its technologies to achieve constitutive as well as inducible functional down-regulation of the expression of the gene targets provided by Merck.
The system permits the down-regulation of a selected target gene to be turned on and off, thereby more closely modeling the dosing of a pharmacologic inhibitor.