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down-regulation

   Also found in: Wikipedia 0.01 sec.
down-regulation /down-reg·u·la·tion/ (doun reg-u-la´shun) a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent.
down-regulation
[doun reg-u-la′shun]
a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually caused by long-term exposure to the agent. See also up-regulation .

down-regulation [down-reg-u-la´shun]
a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent. See also up-regulation.


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Mechanisms that may explain nonmonotonic effects of EDCs include dose-dependent up- or down-regulation of hormone receptors, receptor saturation at high doses, and non-receptor-mediated mechanisms of effect.
They discuss transformation methods, the design of transgenes, uses of transgenic maize in research, expression of reporter genes, down-regulation of gene activity, gene isolation, different technologies, the analysis of plants, and experiments and breeding with transgenes, with laboratory protocols, materials, and notes on troubleshooting and pitfalls.
Down-regulation of E-3GnT1 reduces the number of glycans, leading to greater movement by invasive cancer cells.
 
 
 
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