down-regulate


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Related to down-regulate: Up-regulation

down-regulate

to induce a reduction in the level of expression of a gene by genetic means.
References in periodicals archive ?
SANGUINATE(TM) is an investigational biopharmaceutical product that facilitates the transfer of oxygen to oxygen-deprived cells and tissues and is also shown to down-regulate the inflammatory response in blood samples of Sickle Cell Disease (SCD) patients.
Laboratory data indicate that PROCHYMAL is able to down-regulate the production of pro-inflammatory cytokines, including tumor necrosis factor-alpha or TNF-alpha and interferon-gamma.
NeuroVax(TM) has been shown to stimulate strong, disease-specific, cell-mediated immunity in nearly all patients treated and appears to work by enhancing levels of FOXP3+ Treg cells that are able to down-regulate the activity of pathogenic T-cells that cause MS.
In a report published 15 March 2004 in The Journal of Immunology, Hancock and colleagues write that LL-37 up-regulates genes linked with the inflammation that kills microbes, but down-regulates those linked with the inflammation that promotes septic shock, suggesting that LL-37 serves as a watchdog to control inflammatory processes.