Down Regulation

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Downregulation

Cell biology The reduction of a cell’s response to a hormone or other ligand by internalizing its cognate receptor and degrading it within a coated pit; downregulation is a mechanism by which receptors respond to an excess of ligands
Genetics The decrease of a gene’s transcriptional machinery usually by a DNA-binding protein that acts on a regulatory region

down regulation

means of controlling hormone action where the number of hormone receptors at the cell surface is decreased by internalization of the receptor complex.

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