down regulation


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Related to down regulation: Upregulate
Cell biology The reduction of a cell’s response to a hormone or other ligand by internalizing its cognate receptor and degrading it within a coated pit; downregulation is a mechanism by which receptors respond to an excess of ligands
Genetics The decrease of a gene’s transcriptional machinery usually by a DNA-binding protein that acts on a regulatory region

down regulation

means of controlling hormone action where the number of hormone receptors at the cell surface is decreased by internalization of the receptor complex.
References in periodicals archive ?
However, troglitazone along with trigonelline treated adipocyte shows significant down regulation of PPAR[gamma] transcript level as compared with troglitazone alone treated cells (Fig.
They observed that claudin down regulation was preceded by up regulation of another protein called SNAIL1 that suppresses claudins.
Dopamine pretreatment was not additive with PKC stimulated DAT phosphorylation or down regulation of transport activity, suggesting dopamine induced DAT down regulation may be PKC dependent.
Washington, January 15 (ANI): A team of researchers lead by scientists at Barts and The London School of Medicine and Dentistry has shown that down regulation of an enzyme called phospholipase C?
A good siRNA design reduces off-target effects and leads to down regulation of all types of genes, not just the historically easy-to-knock-down high expressors," said Dr.
DAT undergoes functional down regulation and increased phosphorylation and internalization in response to PKC activation.
Conversely, in our animal research consisting of mice infected with H1N1 that typically succumb to inflamed lungs caused by an over reactive immune response, we witnessed a down regulation of the response and significantly less lung inflammation in the treated mice when compared to their sham-treated counterparts," continued Petrie.
The authors noted that the findings suggest the method presented has potential for assessing target down regulation by GTI-2040 in a clinical setting.
A promising new direction for drug development involves approaches designed to overcome treatment resistance due to over-expression of anti-apoptotic genes or down regulation of pro-apoptotic genes.
Notably, complete responses in the clinical trial directly correlated with down regulation of the R2 intracellular target of GTI-2040, and this was statistically significant with a P value less than 0.
In addition, the subsequent down regulation of these growth factors has positive long-term safety implications since continued, high level expression of these growth factors may not be desirable.
Scheld commented, "The down regulation of multiple pro-inflammatory cytokines in response to this siRNA administration is striking and encouraging for further studies.