down regulation


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Related to down regulation: Upregulate
Cell biology The reduction of a cell’s response to a hormone or other ligand by internalizing its cognate receptor and degrading it within a coated pit; downregulation is a mechanism by which receptors respond to an excess of ligands
Genetics The decrease of a gene’s transcriptional machinery usually by a DNA-binding protein that acts on a regulatory region

down regulation

means of controlling hormone action where the number of hormone receptors at the cell surface is decreased by internalization of the receptor complex.
References in periodicals archive ?
The result is malfunctioning of CTLA-4 and may affect the down regulation of T cells (Al Fadhli, 2013).
ERP-FG= Modelo fator geral, ERP_2F=Modelo com dois fatores: up regulation (5 itens), down regulation (7 itens).
However, troglitazone along with trigonelline treated adipocyte shows significant down regulation of PPAR[gamma] transcript level as compared with troglitazone alone treated cells (Fig.
They observed that claudin down regulation was preceded by up regulation of another protein called SNAIL1 that suppresses claudins.
Muscle fatigue with an aberrant spinal cord reflex preventing activation of golgi tendon organs in the muscle also leads to hyper-stimulation without down regulation.
In a previous publication (24) we have demonstrated that the proliferative response of mononuclear cells from patients with Chagas' disease to bands of soluble, epimastigotes and trypomastigotes, antigens was poor with an important down regulation (DR) that was more frequent and intense with soluble antigens of trypomastigotes.
It has also shown in previous studies that dopamine induces down regulation of DAT and cocaine induces up regulation of DAT by changing the surface level expression.
He told the European Society of Human Reproduction and Embryology (ESHRE)annual conference in Berlin: ``The favourable outcome may be explained by a tranquillising effect which leads to stress reduction and down regulation of the autonomic nervous system.
Il-Moo Chang (Korea) - Study on the Potential Anti-cancer Activities of Iridoids through the Down Regulation of Constitutive STAT3 Activation in Human Prostate Carcinoma DU145 Cells
Oxidative stress in the lungs of COPD patients can result in corticosteroid insensitivity due to oxidative stress-induced down regulation of histone deactylase 2 (HDAC2) expression and activity caused by activation of PI3K.
Washington, January 15 (ANI): A team of researchers lead by scientists at Barts and The London School of Medicine and Dentistry has shown that down regulation of an enzyme called phospholipase C?