doubling time


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.

doubling time

the time it takes for the number of cells in a neoplasm to double, with shorter doubling times implying more rapid growth.
Experimental biology The time necessary for a zygote or cells in culture to increase two-fold; the doubling time is usually longer than the average generation time of the individual cells of the population as there are growth constraints on the population—e.g., nutritional, senescence, death
Oncology A parameter used to determine tumour aggressiveness, which serves to prognosticate, measure therapeutic success, and quantify tumour kinetics and growth rate

doubling time

Oncology A parameter used to determine tumor aggressiveness, which serves to prognosticate, measure therapeutic success, and quantify tumor kinetics and growth rate. Cf Gompertzian growth curve.

doub·ling time

(dŭb'ling tīm)
The time it takes for the number of cells in a neoplasm to double, with shorter doubling times implying more rapid growth.

doubling time

or

generation time

(in microbiology) the time in which the number of cells in a population doubles.
References in periodicals archive ?
Overall doubling time of 3 cell lines was reduced in the presence of CBS, while for 2 cell lives FBS proved to be better growth stimulant.
0], given that, where [gamma] is the duration of the incubating period, [alpha] is the duration of the symptomatic period, and [tau] is the doubling time (7).
To answer these questions, we must know what doubling time is and its strengths and limitations in the defense of an allegation of a delay in the diagnosis of cancer.
Serial [beta]-subunit human chorionic gonadotropin doubling time as a prognosticator of pregnancy outcome in an infertile population.
We have strong data telling us that people with rapid doubling times who fail early and have higher Gleason scores are likely to die from this disease.
Patients with calcitonin doubling times of less than 2 years were classified as high risk and patients with calcitonin doubling times of 2 years and higher were classified as low risk.
Of these patients, 35% have undergone treatment for their cancer based on a rapid PSA doubling time (19%), grade progression (7%), or patient choice (9%), and 65% remain on active surveillance, he said.
Rapid PSA progression has generally been defined as a doubling time of less than 3 years.
The criteria for intervention on a program of watchful waiting or "active surveillance" should include PSA doubling time or grade progression, he advised.
Shorter doubling times are important as the slow growth rate of embryonic stem cells--most have a doubling time of 32 hours or more is often a limiting factor in experiments using these cells.
Vaccination was associated with a significant increase in PSA doubling time and clearance of circulating tumor cells.
High Dose Patient Group Shows Statistically Significant Increase in PSA Doubling Time