Most of the DNA damage caused by oxidative stress can be repaired by various repair systems present in the cells, such as base excision repair, nucleotide excision repair, or DNA double-strand break
It could also inhibit recruitment of double-strand break
resection factors (i.
On the other hand, BRCA1 interacts with RAD51 recombinase (RAD51) during homologous recombination mediated DNA double-strand break
repair forming a nucleoprotein filament on DNA and its mutation can increase the risk of breast cancer (9-11).
Polymorphisms in DNA double-strand break
repair genes and skin cancer risk.
DNA double-strand break
(DSB) is considered the most critical type of DNA damage, inducible by ionizing radiation (IR) or a subset of drugs used in cancer chemotherapy.
Partners and pathways: repairing a double-strand break
He presents an overview of various double-strand break
(DSB) repair mechanisms, and discusses single-strand annealing, mitotic gene conversion, and break-induced replication.
This discovery demonstrated that in normal circumstances cells accurately distinguish telomeric ends from random double-strand break
ends and protect the former from irregular end-joining reactions.
The double-strand break
by ionizing radiation signal sensed by ATM is transduced by Chk2 (Matsuoka et al.
A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break
Sigma has designed CompoZr ZFNs that will produce a knockout in each gene by inducing a double-strand break
at a defined site within the gene's first three exons.
After a double-strand break
, sirtuin rushes to the site to help knit the two parts of the chromosome back together.