double dummy

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double dummy

A technique for retaining the blinding of a clinical trial, where the two treatments cannot be made identical. Supplies are prepared for Treatment A (active and indistinguishable placebo) and for Treatment B (active and indistinguishable placebo); subjects then take two sets of treatment, either A (active) and B (placebo), or A (placebo) and B (active).
References in periodicals archive ?
PEARL II, a randomised, parallel-group, double-blind, double-dummy, phase 3 trial comparing ulipristal acetate versus the injectable GnRH agonist (leuprolide acetate) involved 307 patients.
The study which is a randomized, double-blind, double-dummy, two-arm study is targeted to enroll 744 patients.
As the authors discuss, the optimal trial design would have been a head-to-head comparison between olopatadine and fluticasone with the incorporation of a double-dummy design with eye drop patients receiving saline nasal sprays and nasal spray patients receiving saline eye drops.
Pharma's pivotal Phase 3 clinical trial was a multicenter, randomized, observer-blind, actively-controlled, double-dummy, parallel group study that compared the efficacy of APF530 with palonosetron.
There are currently 21 clinical research sites with IRB approval to participate in the six-month, randomized, double-blind, double-dummy study.
The efficacy of the product was demonstrated in a double-blind, double-dummy placebo-controlled trial in which 128 subjects from Toronto were randomized into one of four arms: placebo, two whole 60-mg ALO-01 capsules, crushed pellets from two 60-mg ALO-01 tablets, or 120 mg of morphine sulfate solution.
The clinical study is a randomized, double-blind, double-dummy design that is expected to enroll approximately 180 patients into two parallel treatment arms.
Dr Laetitia Albano from the Centre Hospitalier Universitaire de Nice, France, who presented the study results at the American Transplant Congress, commented: 'The OSAKA study complements the previous findings of a recent double-blind, double-dummy comparison of tacrolimus QD and BID, and demonstrates the similarity in use of tacrolimus QD and BID in an open-label setting which more closely represents clinical practice.
He reported on 546 patients with secondarily infected dermatitis who participated in a phase III, randomized, double-blind, double-dummy clinical trial conducted at 109 centers in North America, Europe, Asia, and Africa.
Study A0221048 was a randomized, double-blind, double-dummy, placebo-controlled, parallel-group, multicenter trial to compare the efficacy and safety of a flexible dose regimen of fesoterodine to placebo in subjects with symptoms of overactive bladder, including nocturnal urinary urgency.
Two-Year Results of Envarsus (Once-daily MeltDose Tacrolimus Tablets) vs Prograf (Twice-daily Tacrolimus Capsules): A Phase 3, Double-Blind, Double-Dummy, Multi-Center, Prospective, Randomized Study L.
The study included a double-dummy design, so each patient's treatment was fully blinded.