dot positivity

dot positivity

A rarely used term of art referring to minimal positive staining of a particular antigen (in dots, hence the name) due to aggregation of staining material in the Golgi apparatus by immunohistochemistry, which serves to establish the cell’s lineage—e.g., T cells, Ewing sarcoma cells, fibrosarcoma, neuroblastoma, etc.
References in periodicals archive ?
Cytochemically, these cells were negative for myeloperoxidase, Sudan black, acid phosphatase and periodic acid Schiff, while few cells showed granular and dot positivity with non-specific esterase as described in an older literature [5].