, scientists will continue to miss important health impacts--both bad and good--of pollutants, drugs, and other agents.
In this trial the 100 mg and 50 mg daily doses
of Reverset were less effective than the 200 mg dose
, with viral load decreases of 0.
Hopefully experts will look closely at the dosing issue, and the possibility of testing one or more doses
above 200 mg.
The researchers affirm that there were no differences in efficacy among the three treatment groups; moreover, within the limits set by the study, the single dose
of levonorgestrel was at least as effective as the split dose
: 4 doses
, but 3 doses
meet requirement for ages 7-17 years if at least one was on or after the 2nd birthday.
There was also a dosedependent decrease in uptake in response to sialagogue stimulation with higher doses
of radioiodine, which affected the parotid glands more than it did the submandibular glands.
Dosing of the remaining three groups will proceed sequentially, with progressively higher doses
to be administered to the next group only if the dosage in the prior lower dose
group is determined to be safe and well-tolerated.
Since 2000, the Ingelheim, Germany-based company has donated some 400,000 doses
of its drug to prevent infections in newborns in dozens of developing countries.
A previous bioavailability study had predicted that the plasma concentrations, and therefore the antiviral response, of the 400 mg tablet dose
would be comparable to the highest (200 mg) dose
of the oral solution used in the Phase 2a study.
Developmental exposure to low doses
of EDCs may not lead to malformation or to anything you can look at and immediately recognize as a problem," she says.
For students who completed a behavioral-treatment program, those taking low doses
of stimulant medication were more likely to get schoolwork done and to do it more accurately than when they were taking a placebo pill," says psychologist Steven W.
5 mg and 25 mg doses
of Proellex exhibited a dose
-dependent reduction in distress but the reductions did not achieve statistical significance (3.