dose-response curve


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curve

 [kerv]
a line that is not straight, or that describes part of a circle, especially a line representing varying values in a graph.
dose-effect curve (dose-response curve) a graphic representation of the effect caused by an agent (such as a drug or radiation) plotted against the dose, showing the relationship of the effect to changes in the dose.
growth curve the curve obtained by plotting increase in size or numbers against the elapsed time.
oxyhemoglobin dissociation curve a graphic curve representing the normal variation in the amount of oxygen that combines with hemoglobin as a function of the partial pressures of oxygen and carbon dioxide. The curve is said to shift to the right when less than a normal amount of oxygen is taken up by the blood at a given Po2, and to shift to the left when more than a normal amount is taken up. Factors influencing the shape of the curve include changes in the blood pH, Pco2, and temperature; the presence of carbon monoxide; alterations in the constituents of the erythrocytes; and certain disease states.
pulse curve sphygmogram.
Spee curve (curve of Spee) the anatomic curvature of the occlusal alignment of teeth, beginning at the tip of the lower canine, following the buccal cusps of the premolars and molars, and continuing to the anterior border of the ramus.
strength-duration curve a graphic representation of the relationship between the intensity of an electric stimulus at the motor point of a muscle and the length of time it must flow to elicit a minimal contraction; see also chronaxie and rheobase. In cardiac pacing it is useful in determining characteristics of a particular pacing electrode and determining the most efficient selection of pacing parameters for an appropriate safety margin.
survival curve a graph of the probability of survival versus time, commonly used to present the results of clinical trials, e.g., a graph of the fraction of patients surviving (until death, relapse, or some other defined endpoint) at each time after a certain therapeutic procedure.

dose-·re·sponse curve

a graph showing the relationship between (for example, dosage of a drug, infectious agent) and the biologic response.

dose-response curve

A graphic representation of the effects that varous doses of an agent–eg, ionizing radiation or a chemotherapeutic agent, have on a given parameter–eg, cell viability, mutation frequency, DNA damage, tumor growth or metastasis or other behavior Therapeutics A graphic representation of the effectiveness or toxicity of a drug vs the dose administered
References in periodicals archive ?
The shape of the dose-response curve for radiation-induced neoplastic transformation in vitro: evidence for an adaptive response against neoplastic transformation at low doses of low-LET radiation.
Without solid scientific backing for the shape of dose-response curves, particularly in the low-dose region, government agencies use linear non-threshold extrapol ation models as default risk assessment tools [National Research Council (NRC) 2009].
2+] transient traces revealed that increasing concentrations of BPA progressively increased the rate of decline (Figure 3A, bottom), producing a monotonic dose-response curve (Figure 3B).
30] value was estimated from the dose-response curves of each drug administered individually, i.
The dose-response curve of Ang II-induced portal contraction after TF administration was similar to the curve after administration of the Ang II receptor blockers Valsartan.
1) and, furthermore, that the dose-response curves for both methods in Digibind-free and Digibind-loaded serum samples overlap.
m] /100 in animals if the dose-response curve is linear below the PoD.
For the assays in which the responses fell over the full sigmoid dose-response curve, a logistic transformation was used.
Observations on the dose-response curve for arsenic exposure and lung cancer.
The dose-response curve also was significant: Patients taking the highest dose of carbidopa-levodopa benefitted more than those on the other two doses.
We saw a nice dose-response curve regarding LDL, HDL, and total cholesterol, with increased isoflavone intake," he said.