The company added that the Phase 1 study of PTG-300 established pharmacodynamic-based clinical proof-of-concept by achieving dose-related
and sustained reductions in serum iron levels in normal healthy volunteers.
Antipsychotics such as haloperidol and risperidone are associated with a significant and dose-related
increase in mortality in elderly patients with dementia, compared with antidepressants or nonuse, a retrospective case-control study involving 90,786 patients has found.
There was a dose-related
response: the higher the cotinine levels, the poorer the gross motor skills.
Lairson cautioned that benztropine is a drug with dose-related
adverse side effects, and has yet to be proven effective at a safe dose in human MS patients.
Our results from MTT assay suggest that biochanin A induces a dose-related
inhibition of MCF-7 and SK-BR-3 cell viability at 50 [micro]M.
In the tenth year of follow-up, women who had consumed walnuts regularly--one to three servings per month, one servings per week, and more than two servings per week--showed a dose-related
decrease in heir association with diabetes, compared with those who rarely or never ate them.
A thorough, dose-related
assessment of side effects remains to be conducted.
At 12 weeks, there was a dose-related
response in inflammation in the most-diseased vessels.
This study aimed to determine the minimum anesthetic concentration (MAC) and dose-related
cardiovascular effects of isoflurane during controlled ventilation in cinereous vultures (Aegypius monachus).
Dextropropoxyphene causes dose-related
cardiac conduction abnormalities which could lead to dangerous irregularities in heart rhythm and rate, including cardiac arrest and death.
The effect was dose-related
, with higher nut consumption producing greater cholesterol-altering effects.
833) investigated whether 33 men that were occupationally exposed to benzene had higher frequencies of sperm aneuploidy than 33 unexposed men and whether the relationship was dose-related