dose escalation

dose escalation

A progressive increase in the strength of any treatment (e.g., a drug or a radiation dose), to improve its tolerability or maximize its effect.
References in periodicals archive ?
This Phase 1b/2 open-label, dose escalation study evaluates margetuximab, an Fc-optimized anti-HER2 monoclonal antibody, in combination with pembrolizumab, an anti-PD-1 antibody.
According to the companies, with both doses having been deemed safe, the MFDS has approved dose escalation and an updated study design.
In the treatment of gout, dose escalation of allopurinol to achieve target serum urate levels at or below 6 mg/ dL appears safe and effective, even among patients with chronic kidney disease, according to a new open-label, extension study.
Gradual dose escalation of allopurinol achieved target serum urate levels without causing excess adverse effects in patients with gout who tolerated but responded inadequately to creatinine clearance-based dosing, including in patients with chronic kidney disease, investigators reported in Annals of the Rheumatic Diseases.
The lithium salt of GLA (LiGLA) can be administered intravenously and a dose escalation study of a 10 day infusion followed by oral therapy in patients with inoperable pancreatic cancer was carried out in 48 patients in two centres.
The case is unique because the patient experienced an impressive and extremely rapid response to sunitinib dose escalation to 50 mg/day delivered in continuous daily administration form, as opposed to the conventional dose of 50 mg/day for 4 of 6 weeks dosing on which the patient had a disease relapse.
A maximum of three cohorts will be enrolled in the REOLYSIN(R) dose escalation portion.
Some experts recommend clinical and laboratory monitoring more often than once per month, and in particular, would include monitoring of liver function tests at baseline, prior to dose escalation and at two weeks post dose escalation.
But many people do not stop using cocaine once they start, and, he notes, "even if there is no dose escalation, one becomes more vulnerable to seizures over time.
titled, "Dose Escalated, Hypofractionated Radiotherapy Using Helical Tomotherapy for Inoperable Non-Small Cell Lung Cancer: Preliminary Results of a Risk-Stratified Phase I Dose Escalation Study," evaluates a study devised to test the safety of escalating the biologically-effective tumor dose via hypofractionated treatment regimens using 25 fractions over five weeks.
The trial is to start dose escalation in healthy volunteers and graduate to patients when a predefined knockdown target is achieved.
EpiTan Limited [ASX: EPT], Melbourne, Australia, has announced better than expected efficacy in its implant dose escalation trial which commenced in November 2003.