dose dependence

dose dependence

Concentration dependence Therapeutics The change in certain pharmacokinetic parameters–clearance, half-life, bioavailable fraction–as a function of administered dose
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12] These inhibitors are thought to produce adverse secondary effects with similar frequency, severity, and dose dependence, but further studies are required to confirm the incidence of adverse events, especially in relation to the lesser prescribed vardenafil and tadalafil.
Research shows that various components of the placebo effect -- for example, the paraphernalia of care (pills and syringes) and the patient-provider relationship -- can be added incrementally in a manner analogous to dose dependence (the higher the dose, the greater the effect).
The NPL/Harwell data display significant dose dependence for the TC values and TC curve shapes.
Both dosimetry systems exhibit a small dose dependence in the measured temperature coefficient (Table 1).
He speculated that it may be an issue of dose dependence, based on data from the phase II RE-DEEM study of dabigatran in patients with acute coronary syndrome.
Strongly superlinear dose dependence of thermoluminescence in synthetic quartz.
This objective required fulfillment of numerous criteria: low background with no interference from endogenous hormone, robust and statistically significant responses, dose dependence, and low threshold.
Additionally, the technique does not always show dose dependence in an extensive concentration range of analytes, exemplified by the so called high-dose hook effect (3).
The most common adverse events were grade 1-2 fatigue (24% of patients), nausea (17% of patients) and fever (15% of patients), with no clear dose dependence.
Northern analysis was used to confirm that HDI increased message levels of these four genes and to further explore the dose dependence and kinetics of the response.
To facilitate investigations on the dose dependence and kinetics of HDI's effects on human airway epithelial cells, we developed and characterized an in vitro exposure system.
Is there a dose dependence for acrolein associated with adduct formation?