dosage regimen

dosage regimen

The schedule of doses of a therapeutic agent per unit of time, including: the time between doses (e.g., every 6 hours) or the time when the dose(s) are to be given (e.g., at 8 a.m. and 4 p.m. daily), and the amount of a medicine (e.g., number of capsules) to be given at each specific time.
References in periodicals archive ?
The optimized dosage regimen for the reference drug (informed in package inserts to guide prescribers and patients) relies on the empiric evidence arising from clinical trials conducted by the pharmaceutical company.
Sponsored by specialist Spanish biotech company Araclon Biotech, a Grifols company, this phase II of the study is designed to establish the dosage regimen for the therapy, as well as confirm the treatment safety and tolerability data obtained in phase I.
Traditionally, medications are measured in the appropriate matrix (serum, plasma, or whole blood) and are used to individualize the dosage regimen with the intent to maximize efficacy and minimize toxicity.
This study showed that changing the dosage regimen of morphine administration could be useful for the management of withdrawal syndrome and cortisol (as the main marker of anxiety) of the cessation period.
From this study, low dosage regimen may suffice in our patients, but the sample size may be too small to bring out minor differences.
Of the 1092 consecutively admitted cirrhotics, 198 were excluded for hepatocellular carcinoma, 710 for non-HCV-related disease (586 HBV, 65 alcoholic, 58 biliary cirrhosis and one patients with haemochromatosis), 37 for inadequate liver function (Child-Pugh class C), 28 for chronic invalidating disease (such as unstable cardiovascular disease, chronic renal failure, or severe chronic obstructive lung disease), 23 for being older than 65 years, 5 for previous combination antiviral therapy, 28 for refusing to be treated, and 50 patients with moderate hypersplenism and portal hypertension received pegylated/standard IFN-[alpha] plus ribavirin combination therapy with a low accelerating dosage regimen for 48 weeks (partial results has been described in previous study (5)).
For patients on twice a day dosage regimen, reduce the morning dose to 75% and should be given at Iftar, reduce the night dose to 50% and should be taken at Sehar.
We are awaiting Ethics Committee approval for a second prospective study that will include a control arm and different dosage regimen.
Further research is needed to confirm these findings and to determine the optimal dosage regimen.
It is difficult to disagree about the pathophysiology of acetazolamide causing corneal oedema, but we must note that it is a drug used for glaucoma treatment, (2) and the dosage regimen is usually higher than that prescribed for the prevention of AMS.
We expect the open-label trial results to confirm our hypothesis that CaPre(R) is effective at a smaller dose and at a better dosage regimen than competitive products, increasing patient compliance, a major factor for the viability of a chronic regimen," she added.
They assume the proposed dosage regimen will hit the target exactly - there is no way to evaluate, control, and minimise the error with which the target can be hit in the real world.