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dornase alfa |
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dornase alfa /dor·nase al·fa/ (dor´naz al´fah) recombinant human deoxyribonuclease I (DNase I) used to reduce the viscosity of sputum in cystic fibrosis.
dornase alfa (dor´nās al´f n brand name: Pulmozyme; drug class: recombinant human deoxyribonuclease (DNase); action: reduces sputum viscosity; uses: cystic fibrosis; reduces incidence of pulmonary infection, improves pulmonary function. dornase alfa Pulmozyme Pharmacologic class: Recombinant human deoxyribonuclease I Therapeutic class: Cystic fibrosis agent, mucolytic enzyme, respiratory inhalant Pregnancy risk category B ActionSelectively cleaves to DNA in sputum, decreasing viscosity of pulmonary secretions AvailabilityInhalation solution: 2.5-mg ampule (1 mg/ml) ⊘Indications and dosages ➣ To reduce respiratory tract infections and improve pulmonary function Adults and children older than age 5: One ampule (2.5 mg) inhaled once daily Contraindications• Hypersensitivity to drug, its components, or products derived from Chinese hamster ovary cells PrecautionsUse cautiously in: Administration• Don't shake or dilute drug.
Adverse reactionsCV: chest pain EENT: conjunctivitis, rhinitis, pharyngitis, hemoptysis, voice changes Respiratory: dyspnea, increased sputum, wheezing Skin: rash, urticaria, pruritus Other: hypersensitivity reactions InteractionsNone known Patient monitoring• Assess patient periodically. Report improvement in dyspnea and sputum clearance. Patient teaching• Teach patient how to use nebulizer. |
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| Food and Drug Administration (FDA), including dornase alfa, tobramycin, macrolides and digestive enzymes, will be permitted in the trial. |
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