dornase


Also found in: Dictionary.

dor·nase

(dōr'nās),
Obsolete contraction of deoxyribonuclease.
See also: streptodornase.

dornase

(1) Deoxyribonuclease I, EC 3.1.21.1.
(2) Deoxy-ribonuclease II, EC 3.1.22.1.

dornase

(dor′nās)
Short for deoxyribonuclease.

dornase alfa

An enzyme that lessens the viscosity of sputum by cleaving DNA deposited in it. It is used to treat patients with cystic fibrosis, who have exceptionally thick pulmonary secretions that are hard to expectorate.

pancreatic dornase

Dornase prepared from beef pancreas, used to loosen thick pulmonary secretions.

dornase

a shortened term for deoxyribonuclease; also a word termination, as in streptodornase.
References in periodicals archive ?
TWO) disclosed on Wednesday that it has filed a Phase 1 Clinical Trial Application with the Dutch Healthcare Authority for its planned dornase alfa biosimilar, JHL1922, for the improvement of pulmonary function in cystic fibrosis patients.
Prescribe inhaled dornase alpha and inhaled tobramycin for maintenance pulmonary treatment of moderate to severe cystic fibrosis (CF).
Hence, the importance of dornase alfa's mode of mechanism of breaking down extracellular DNA to decrease the viscosity of mucus.
For example, in children there is 16-20% adherence recorded for dietary supplementation but up to 67-84% for dornase alpha (Modi et al 2006).
Dornase alfa (Pulmozyme) treatment reduced exacerbations in healthy cystic fibrosis patients who were 6-10 years old.
s dornase alfa, which was what Hussar described as the first major advance for cystic fibrosis patients in 30 years.
7% of the predicted normal value of FEV1 and the use of concomitant medications including inhaled antibiotics, dornase alfa (PULMOZYME([R])), and oral macrolide antibiotics was similar between the treatment groups.
M2 PHARMA-December 21, 2017-JHL submits clinical trial application with the Dutch Healthcare Authority for proposed clinical trial of Dornase Alfa Biosimilar in the Netherlands
M2 EQUITYBITES-December 21, 2017-JHL submits clinical trial application with the Dutch Healthcare Authority for proposed clinical trial of Dornase Alfa Biosimilar in the Netherlands
Sputum induction by various inhalants in patients with suspected pulmonary TB included agents like 10% normal saline, sulfur dioxide, pancreatic dornase, acetyl cysteine, and sterile water (Yue and Cohen, 1967).
A two-year randomized, placebo-controlled trial of dornase alfa In young patients with cystic fibrosis with mild lung function abnormalities.
The two most common mucolytics on the market today are dornase alfa (Pulmozyme) and N-acetylcysteine (NAC), commonly referred to as Mucomyst.