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The new definition (resistant to imipenem, meropenem, doripenem, or ertapenem or documentation that the isolate possesses a carbapenemase) is to be used with current CLSI breakpoints (10).
Therapeutic use: Doripenem (7) is a carbapenem bactericidal antimicrobial that inactivates essential penicillin-binding proteins in the cell wall, inhibiting cell wall biosynthesis, thereby resulting in bacterial cell death.
BEERSE, Belgium, July 19 /PRNewswire/ -- Janssen-Cilag International NV announced today that the European Medicines Agency (EMEA) has accepted for review a Marketing Authorization Application (MAA) for doripenem, an investigational carbapenem antibiotic for the treatment of nosocomial pneumonia (NP), including ventilator-associated pneumonia (VAP), complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI).
5 g/d for 28 d After identification of pathogen Continuation of doripenem At discharge Oral amoxicillin, 1,500 mg/d, and minocycline, 200 mg/d, until follow-up visit Postoperative complications None Outcome Survived * CT, computed tomography; +, positive; -, negative; L, left; R, right; MLST, multilocus sequence typing; ST, sequence type; CC, clonal complex; A, adenine; G, guanine; T, threonine; I, isoleucine; D, aspartic acid; G, glycine.
Contract awarded for event 3153/2013 doripenem, parenteral use powder 500 mg 20 ml vial
The antibiotic pipeline today * Novel Compound Class MOA Dalbavancin Lipoglycopeptide No ([dagger]) Iclaprim Diaminopyrimidine No Oritavancin Glycopeptide No Telavancin Lipoglycopeptide Yes ([double dagger]) Ceftobiprole Cephalosporin ([section]) No Cethromycin Ketolide No Doripenem Carbapenem No Faropenem Penem No Prulifloxacin Quinolone No Compound Formulation Status Dalbavancin IV Filed Iclaprim IV Phase 3 Oritavancin IV Phase 3 Telavancin IV Phase 3 Ceftobiprole IV Filed Cethromycin Oral Phase 3 Doripenem IV Approved Faropenem Oral Filed ([paragraph]) Prulifloxacin Oral Phase 3 * Adapted from ref.
The Company has provided such innovative medicines as Crestor and Doripenem, which have been successfully delivered to millions of patients.
org), were as follows: sulbactam/ampicillin, >128 mg/L; piperacillin, >128 mg/L; tazobactam/piperacillin, >128 mg/L; cefotaxime, >64 mg/L; ceftazidime, >64 mg/L; aztreonam, 64 mg/L; cefmetazole, >128 mg/L; imipenem, 8 mg/L; meropenem, 32 mg/L; and doripenem, 32 mg/L.
Contract awarded for event 3081/2013 doripenem powder for use parenteral 500 mg vial 20 ml
Data from this study show that although ertapenem (Merck's Invanz), meropenem (AstraZeneca's Merrem, generics), and imipenem-cilastatin (Merck's Primaxin) have near equal high rates of hospital formulary inclusion and formulary uptake of doripenem (J&J's Doribax) has rapidly climbed over the last five years, the perceived therapeutic equivalence of carbapenems is leading P&T committees to limit the number of carbapenems on formulary.
Other excluded studies were those that did not distinguish the outcomes for infected patients from those for colonized patients and studies that reported on isolates resistant to a carbapenem other than imipenem, meropenem, or doripenem.
MICs of amikacin, aztreonam, cefotaxime, cefepime, ciprofloxacin, colistin, doripenem, ertapenem, gentamicin, imipenem, meropenem, polymyxin B, tetracycline, tigecycline, and trimethoprim/sulfamethoxazole were determined by using reference broth microdilution (BMD) with panels prepared in-house according to Clinical and Laboratory Standards Institute (Wayne, PA, USA) guidelines (16) and stored at -70 [degrees]C until use.