dopamine transporter


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dopamine transporter (DAT),

a protein, found, for example, in the terminal of a presynaptic neuron, which decreases the concentration of dopamine near the synapse by effecting its reuptake into the presynaptic neuron.
References in periodicals archive ?
3:40 Balachandra Gorentla (UND): ACUTE EFFECTS OF DOPAMINE AND TRANSPORT BLOCKERS ON DOPAMINE TRANSPORTER PHOSPHORYLATION AND REGULATION
It further validates the role that Dopamine Transporters play in neurological disorders such as Parkinson's Disease and Attention Deficit/Hyperactivity Disorder," said David Hillson, CEO of Boston Life Sciences.
Mark Hurtt, BLSI's Chief Medical Officer, comments, "The use of imaging techniques and dopamine transporter specific imaging agents has the potential to provide an objective, biologically-based diagnosis for ADHD.
The researchers found that people who had the 10-repeat allele in the dopamine transporter were most likely to engage in adolescent mild rule-breaking behavior, which is positively associated with leadership.
Injectable (ioflupane [123I] injection) "DaTSCAN") is a brain imaging agent to be used in evaluating the distribution of presynaptic dopamine transporters in the striatal region of the brain for diagnosing Parkinson's Syndrome and dementia with Lewy bodies.
Inhibitory effect of reserpine on dopamine transporter function.
Our SPECT study showed a trend toward decreased dopamine transporter density in the brain and Parkinsonism in the follow-up data of patients with REM sleep disorder who had no previous evidence of neurodegenerative disease," Hongyoon Choi, MD, a PhD candidate and researcher in the department of molecular medicine and biopharmaceutical sciences at Seoul National University Bundang Hospital, Sungnam, Korea said.
DaTscan is a radiopharmaceutical approved in the United States for striatal dopamine transporter visualization, using SPECT brain imaging to assist in the evaluation of adult patients with suspected PS to help differentiate PS from essential tremor (ET).
In the study at New York's Cornell University, a dopamine transporter scan conducted using molecular imaging showed the part of the brain where cocaine works "lit up like fireworks" in a vaccinated brain.
BARCELONA -- Severe hyposmia may be associated with a deficiency of striatal dopamine transporter protein and slight cognitive decline - characteristics that could identify people with an increased risk of developing Parkinson's disease, according to preliminary findings from the Parkinson's Associated Risk Study.
The Food and Drug Administration's recent approval of the dopamine transporter radiotracer DaTscan (ioflupane 1-123 injection) provides clinicians with a much-needed diagnostic tool for patients with questionable parkinsonian symptoms and could lead to earlier diagnosis of Parkinson's disease and initiation of therapies to slow or halt disease progression.
In their model of iron deficiency, they noted a decrease in the dopamine transporter (DAT) functioning, both in vitro and in vivo.