DRD2

(redirected from dopamine receptor D2)

DRD2

A gene on chromosome 11q23 that encodes G protein-coupled dopamine receptor D2, which inhibits adenylyl cyclase.

Molecular pathology
Defects in DRD2 are associated with myoclonic dystonia.
References in periodicals archive ?
Certain finds make sense: One region includes the genetic blueprint for a protein called dopamine receptor D2, thought to be the target of some psychiatric drugs.
One of the most encouraging findings for developing treatments is that the research identified a link between schizophrenia and a gene called dopamine receptor D2.
Since genes present in the mesolimbic/mesocortical dopaminergic pathways arc strong candidate genes for possible contributions to differences in substance abuse vulnerability, differences in the expression of the dopamine receptor D2 gene transcript, the gamma-amino butyric acid b1 and b2 ligand-gated ion channels, AGS1, and HRPT were sought.
Moreover, RDS results from a dysfunction in the mesolimbic system of the brain, which directly links abnormal craving behavior with a defect in the dopamine receptor D2 gene (DRD2) as well as other dopaminergic genes (D1, D3, D4, and D5, DATA1, MAO, COMT), including many genes associated with the brain reward function (Tabakoff et al.