DRD2

(redirected from dopamine receptor D2)

DRD2

A gene on chromosome 11q23 that encodes G protein-coupled dopamine receptor D2, which inhibits adenylyl cyclase.

Molecular pathology
Defects in DRD2 are associated with myoclonic dystonia.
References in periodicals archive ?
Fetal alcohol exposure reduces dopamine receptor D2 and increases pituitary weight and prolactin production via epigenetic mechanisms.
Certain finds make sense: One region includes the genetic blueprint for a protein called dopamine receptor D2, thought to be the target of some psychiatric drugs.
One of the most encouraging findings for developing treatments is that the research identified a link between schizophrenia and a gene called dopamine receptor D2.
1 D1 receptors regulate neuronal growth and development, mediate behavioral responses, and modulate D2 receptor-mediated events DRD2 Dopamine receptor D2 11q23 D2 receptors regulate motor activities and information processing in the brain DTNBP1 Dystrobrevin binding protein 6p22 Neurodevelopment and 1 synaptic transmission HLA-DQB1 Major histocompatibility 6p21.
Since genes present in the mesolimbic/mesocortical dopaminergic pathways arc strong candidate genes for possible contributions to differences in substance abuse vulnerability, differences in the expression of the dopamine receptor D2 gene transcript, the gamma-amino butyric acid b1 and b2 ligand-gated ion channels, AGS1, and HRPT were sought.
Moreover, RDS results from a dysfunction in the mesolimbic system of the brain, which directly links abnormal craving behavior with a defect in the dopamine receptor D2 gene (DRD2) as well as other dopaminergic genes (D1, D3, D4, and D5, DATA1, MAO, COMT), including many genes associated with the brain reward function (Tabakoff et al.
Animal studies suggest that autoregulation of the dopamine system via the dopamine receptor D2 (DRD2) plays an important role in the neurobiological effect of lead and iron (Beard and Connor 2003; Cory-Slechta 1995; Erikson et al.