The 5 distinct dopamine receptors
(Dl, D2, D3, D4, and D5) can be grouped into 2 subtypes, based on their coupling with G proteins.
The investigators calculated the proportional reporting ratio, "a ratio similar in concept to the relative risk ratio," between these cases and each individual dopamine receptor
D2 dopamine receptor
gene (DRD2) allele and haplotype frequencies in alcohol dependent and control subjects: no association with phenotype or severity of phenotype.
Addiction and its reward process through polymorphisms of the D2 dopamine receptor
gene: a review.
MDS is thought to be the result of a compensatory up regulation of dopamine receptors
due to the potent receptor blockade of the typical antipsychotics (as demonstrated by the PET scans discussed above).
The study also suggested that lead-exposed mice had lower dopamine receptor
(including DRD2) production, as demonstrated by the difference in recovery rates after being exposed to an irreversible antagonist (Cory-Slechta et al.
Even more interesting, pretreatment with a dopamine receptor
blocking drug had no effect on this finding, suggesting that the dopamine system is not required for this reinstatement effect.
Researchers have studied the effects of dopamine partial agonists (1)-agents that block the activities of the dopamine receptors
In a separate experiment, the mice were treated with the dopamine receptor
suppressors again, and their movements in an open cage were observed.
Selective effects of low-dose D2 dopamine receptor
antagonism in a reaction-time task in rats.
Noble, MD, PhD, a former director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) who has conducted significant research on the A1 allele of the D2 dopamine receptor
gene, believes further knowledge about the A1 allele could lead to the development of dopamine agonists that would act in the same way as alcohol and other abused substances.
The monkeys in the enriched environment had 20 percent more dopamine receptor