At baseline, 35 patients were taking ergotamine-derived dopamine agonists
(EDDA) and 8 were taking non-ergotamine-derived drugs (non-EDDA).
Compared with primary care physicians, surveyed neurologists less frequently use levodopa as first-line therapy for patients with mild disease under the age of 65 and are increasingly using dopamine agonists
and MAO-B inhibitors to manage mild motor symptoms and delay the need for levodopa.
act as a substitute for dopamine and has a similar but milder effect compared with levodopa.
Physicians who prescribe dopamine agonists
should vigilantly monitor their patients, and ensure that patients, families, and caregivers are counseled about [this] risk," the investigators wrote.
One of the major issues in treating RLS with dopamine agonists
is augmentation, meaning symptoms occur earlier in the day due to medication use.
Food and Drug Administration (FDA) from being a monotherapy and adjunct to levodopa (LD) to now being an adjunct to dopamine agonists
To avoid long-term treatment and augmentation, oral iron supplementation is preferred to dopamine agonists
in RLS patients with iron deficiency, but considering the moderate response rate to oral iron alone, a dopamine agonist
or other treatment could be added in selected RLS patients with a low-normal serum ferritin," the researchers wrote.
Meanwhile, the analysis shows the uptake of dopamine agonists
slightly grew as first-line treatments during this time, reaching 14 percent patient share in Q2 2013.
Both attempt to replace the missing dopamine, but the levodopa group restores it artificially, while dopamine agonists
mimic its role by stimulating nerve cells.
Safinamide is an alpha-aminoamide that is currently being developed as an add-on therapy to dopamine agonists
or to levodopa in patients with early or mid- to late-stage Parkinson's disease (PD).
Among their topics are the epidemiology of movement disorders in India and in other countries, less common features in the diagnosis of parkinsonism, nocturnal disabilities in the disease and its management, depression and dementia, dopamine agonists
, the current status of stereotactic surgery for Parkinson's in India, Huntington's disease, dystonia, restless legs syndrome, psychogenic movement disorders, movement disorders in children, and drug induced acute dystonia.
The sparse data available to help guide the management of these patients suggest that suppressing prolactin-secreting adenomas with dopamine agonists
reduces the effects of the tumor and allows the patient to get pregnant without increasing the risk of fetal loss or fetal abnormalities.