dopa


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Related to dopa: dopamine, DOPA decarboxylase

dopa

 [do´pah]
a compound produced by oxidation of tyrosine by tyrosinase; it is the precursor of dopamine and an intermediate product in the biosynthesis of norepinephrine, epinephrine, and melanin. The naturally occurring form is l-dopa (see levodopa), and is used to treat parkinson's disease and other forms of parkinsonism.

do·pa

, DOPADopa (dō'pă),
An intermediate in the catabolism of l-phenylalanine and l-tyrosine, and in the biosynthesis of norepinephrine, epinephrine, and melanin; the l form, levodopa, is biologically active. See: dopa reaction.
Synonym(s): 3, 4-dihydroxyphenylalanine

dopa

/do·pa/ (do´pah) 3,4-dihydroxyphenylalanine, produced by oxidation of tyrosine by monophenol monooxygenase; it is the precursor of dopamine and an intermediate product in the biosynthesis of norepinephrine, epinephrine, and melanin. -dopa is the naturally occurring form; see levodopa.

dopa

(dō′pə)
n.
An amino acid, C9H11NO4, that occurs widely in animals and plants. In humans and other mammals, it is formed in the liver from tyrosine and converted to dopamine in the brain.

dopa

[dō′pə]
an amino acid, produced by oxidation of tyrosine, that occurs naturally in plants and animals. It is a precursor of dopamine, epinephrine, norepinephrine, and melanin. See also dopamine hydrochloride, levodopa.

do·pa

, DOPA (dō'pă)
An intermediate in the catabolism of l-phenylalanine and l-tyrosine, and in the biosynthesis of norepinephrine, epinephrine, and melanin; the l form, levodopa, is biologically active.

DOPA (dihydroxy phenylalanine)

a precursor in the biochemical PATHWAY leading to MELANIN formation in animals. DOPA is not metabolized in individuals with ALBINISM.

DOPA

The common name for a natural chemical (3, 4-dihydroxyphenylalanine) made by the body during the process of making melanin.
Mentioned in: Albinism

do·pa

, DOPA (dō'pă)
Intermediate in catabolism of l-phenylalanine and l-tyrosine and in biosynthesis of norepinephrine, epinephrine, and melanin.

dopa

(dō´pə),
n an amino acid derived from tyrosine that occurs naturally in plants and animals. It is a precursor of dopamine, epinephrine, and norepinephrine.

dopa

L-3,4-dihydroxyphenylalanine. Key intermediate in two pathways; the production of melanins from tyrosine catalyzed by the copper-containing enzyme, tyrosinase, to produce dopa, or the biosynthesis of catecholamines catalyzed by the action of tyrosine. It is used in manganese poisoning. Called also L-dopa and levodopa.
References in periodicals archive ?
Cardiac transmitter stores were depleted, leading to a reduced contribution of "leakage" to transmitter turnover and a reduced requirement for activation of tyrosine hydroxylase, as assessed from measurements of cardiac spillover of DOPA.
Tyrosinase catalyzes the hydroxylation of tyrosine to DOPA and the oxidation of DOPA to dopaquinone as mentioned in the introduction.
Single photon emission computed tomography (SPECT) and positron emission tomography (PET) studies have shown that PD patients exhibit decreased levels of dopamine transporters (DATs) and vesicular monoamine transporter type 2 (VMAT2) and reduced activity of dopa decarboxylase as measured by the conversion of L-dopa to dopamine in the striatum using [[.
The company has also introduced Mucuna Dopa, a natural supplement version of Mucuna pruriens, which contains high concentrations of levodopa, or 1-dopa.
Many autistic children have high levels of homocysteine, (1,5) and methylating dopa increases homocysteine.
Interestingly, the catecholamines, epinephrine and norepinephrine, and L DOPA were not effective inducers of larval metamorphosis of R.
As it turns out, a single iron atom can bind to three DOPA side chains.