Also found in: Dictionary, Wikipedia.
donepezil/do·nep·e·zil/ (do-nep´ĕ-zil) an acetylcholinesterase inhibitor used as the hydrochloride salt for the treatment of mild to moderate symptoms of dementia of the Alzheimer type; administered orally.
A drug, C24H29NO3, that inhibits acetylcholinesterase and is used in its hydrochloride form to treat mild to moderate dementia caused by Alzheimer's disease.
a reversible cholinesterase.
indication It is used to treat mild to moderate dementia in Alzheimer's disease.
contraindications Known hypersensitivity to this drug or to piperidine derivatives prohibits its use.
adverse effects Life-threatening effects include seizures and atrial fibrillation. Other adverse effects are dizziness, somnolence, fatigue, abnormal dreams, syncope, hypotension or hypertension, anorexia, urinary frequency, urinary tract infection, incontinence, rash, flushing, rhinitis, upper respiratory infection, cough, pharyngitis, cramps, and arthritis. Common side effects include insomnia, headache, nausea, vomiting, and diarrhea.
donepezilAricept® Neurology A cholinesterase inhibitor used to maintain cognition in Alzheimer's disease Contraindications Succinylcholine-type anesthesia, sick sinus syndrome, seizures Adverse events N&V, insomnia, muscle cramps, anorexia, fatigue. See Alzheimer's disease.
donepezilAn ACETYLCHOLINESTERASE inhibitor drug used in Alzheimer's disease and other forms of dementia to increase the amount of ACETYLCHOLINE available for nerve transmission. A brand name is Aricept.
A drug commonly prescribed for Alzheimer's disease that provides temporary improvement in cognitive functions for some patients with mild-to-moderate forms of the disease.
Mentioned in: Dementia