domoic acid


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domoic acid

(də-mō′ĭk)
n.
A water-soluble amino acid found in various marine algae that is a potent, often deadly neurotoxin to humans when consumed in contaminated mussels, clams, crabs, and anchovies.

domoic acid

An excitatory kainic acid analogue and neurotoxic glutamate agonist, which ↑ neuronal activity, causing food poisoning

domoic acid

C15H20NO6, a toxin that resembles glutamate, the main excitatory amino acid of the brain. When ingested, it may cause continuous seizures.
CAS # 14277-97-5
See also: acid
References in periodicals archive ?
Domoic acid is structurally similar to glutamine, glutamic acid and kainic acid, all of which can potentially co-occur with DA in sample extracts (Fig.
Domoic acid was isolated originally in Japan some 30 years ago from the red macroalga Chondria armata.
Centers for Oceans and Human Health Center Director Areas of Study Pacific Northwest Elaine Faustman Researchers will study Center for Human toxic algae and how Health and Ocean toxic domoic acid Sciences accumulates in Puget University of Sound shellfish.
Eating shellfish contaminated with domoic acid can cause minor illnesses with flulike symptoms that include vomiting, diarrhea, abdominal cramps and headaches.
Monitoring approaches for early warning of domoic acid events in Washington state.
CONCLUSION: These studies demonstrate that p,p'-DDE--in the absence of PCBs, HCH, chlordane, and PBDEs that co-occur in fetal sea lions--accounts for the synergistic activity that leads to greater sensitivity to domoic acid seizures.
They found domoic acid in the seawater, from which they also isolated two species of Pseudonitzschia.
The study, titled "Variability of Pseudo-nitzschia and domoic acid in the Juan de Fuca eddy region and its adjacent shelves," was published in Limnology and Oceanography and authored by Vera Trainer (NOAA Fisheries); Barbara Hickey and Evelyn Lessard (University of Washington); William Cochlan (San Francisco State University); Charles Trick (The University of Western Ontario); Mark Wells (University of Maine); and Amoreena MacFadyen and Stephanie Moore (University of Washington).
Role of Nitric Oxide in Domoic Acid Induced Hippocamapl
With the domoic acid outbreak in 2002, the number of debilitated sea lions rose tremendously.
An algae-dwelling diatom produces the toxin domoic acid, a glutamate agonist.
At the University of Washington, researchers are studying the toxicity of domoic acid, a naturally occurring toxin produced by marine algae that is responsible for poisoning among Puget Sound residents who consume tainted shellfish.