Dolly

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The name of a sheep famous for being the first mammal cloned from an adult somatic cell. Dolly was grown from an egg, the nucleus of which had been replaced with the DNA from the mammary tissue of a six-year-old ewe

Dolly

the first mammal, a sheep, to be created by the cloning of an adult cell by NUCLEAR TRANSFER (see also ASEXUAL REPRODUCTION). The nucleus from a quiescent (see QUIESCENCE), adult udder cell of a finn Dorset ewe was transferred into an unfertilized OVUM from which the nucleus had been removed i.e. an enucleate OOCYTE, of a Scottish Blackface ewe. Electric current was applied to induce EMBRYO formation and the embryo introduced into a surrogate Blackface ewe. The process was repeated 276 times.

A lamb was born, called Dolly, to the Blackface ewe, but with almost identical genetic make-up to the finn Dorset ewe from which the genetic material derived.

The creation of Dolly demonstrated that adult cells could be reprogrammed for embryo development.

Dolly developed ARTHRITIS at the relatively young age of 5.5 years, and at 6 years was euthanased, due to development of a progressive lung disease. Whether this was a consequence of the cloning process is unknown.

References in periodicals archive ?
Regulars toast the arrival of dollybird teacher Sandra Kelly, played by Michelle Costello, to Killinaskully
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I've never been a babe or a dollybird in my life and I'm certainly not going to start now," she said.
It's a similar story for Banbridge Rangers going into their home game against Fivemiletown, sitting 10 behind the Dollybirds with five games in hand on them.
He'd seen then - sees again now - the unfunny little man's festination as he chases after the scantily-clad dollybirds.
15pm Hacked Off - High Street 2pm & 4pm: Dollybirds - High Street 2.
strike Throw in a decent undercard - Hatton v Kinnock springs to mind - a few dollybirds to hold the round cards (I believe a few BA stewardesses could use the extra cash) and Jeremy Paxman in a bow-tie to referee, and you, sir, have got yourself some primetime televisual entertainment.
The dollybirds disappeared and he was laughed out of VIP areas across the land.
The Dollybirds are seven points clear at the top of Intermediate A after ending Richhill AFC's resurgence.