dolichol


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dol·i·chol

(dol'i-kol),
Polyisoprenes in which the terminal member is saturated and oxidized to an alcohol, usually phosphorylated and often glycosylated; found in endoplasmic reticulum, but not in mitochondrial or plasma membranes; urinary levels are elevated in disorders exhibiting abnormal skin, rectal, or brain profiles in electron microscopy of biopsies; derived from four or more linked isoprene units.

dol·i·chol

(dol'i-kol)
Polyisoprenes in which the terminal member is saturated and oxidized to an alcohol, usually phosphorylated, and often glycosylated; found in endoplasmic reticulum, but not in mitochondrial or plasma membranes; urinary levels are elevated in disorders exhibiting abnormal skin, rectal, or brain profiles in electron microscopy of biopsies.

dolichol

special lipid molecule that links oligosaccharide to asparagine residues in proteins via a pyrophosphate bridge; an example of protein glycosylation.
References in periodicals archive ?
In point of fact, dolichol derivatives, mixture of polyprenols (acyclic isoprenoid alcohols) known as Ropren (Solagran Limited, Melbourne, Australia) commercially used to treat liver diseases, were tested in the treatment of AD in two separate trials conducted in 2005 and 2006 with promising results [http://www.
Ziqiang Guan, an associate research professor of biochemistry in the Duke University Medical School and a contributing author of the study, and his collaborators had previously sequenced the genome of this family and found that the children with RP carry two copies of a mutation at the dehydrodolichol diphosphate synthase (DHDDS) gene, which makes the enzyme that synthesizes organic compounds called dolichols.
Then we gradually learned the truth, that to inhibit cholesterol we must also inhibit Coenyzyme Q10 (CoQ10) and dolichols, key substances vital for health.
It is isolated from the neutral fraction of an extract of spruce needles and belongs to the group of polyprenols: polyisoprenoid alcohols that are transformed into dolichols in the liver (Blogger et al.
Dolichol is a carrier of oligosaccharides in glycoprotein metabolism.
Effects of CC14 poisoning on metabolism of dolichol in RAT liver microsomes and golgi apparatus," Free Radical Research, vol.
Dolichol inhibition contributes to a broad range of conditions such as myopathies, neuropathies, diabetes, and rhabdomyopathies.
1998) DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate.
However, they also compromise the production of several other substances vital for health, including coenzyme Q10 critical for energy metabolism and heart and muscle health, and dolichol, a fatty molecule crucial in the assembly of cellular proteins.
In CDG cases, the conversion from polyprenol to dolichol is blocked by a mutation in the SRD5A3 gene.
Gamma-glutamyl transferase, aspartate and alanine aminotransferases and their ratio, mean cell volume and urinary dolichol in pregnant alcohol abusers.