dolichol


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dol·i·chol

(dol'i-kol),
Polyisoprenes in which the terminal member is saturated and oxidized to an alcohol, usually phosphorylated and often glycosylated; found in endoplasmic reticulum, but not in mitochondrial or plasma membranes; urinary levels are elevated in disorders exhibiting abnormal skin, rectal, or brain profiles in electron microscopy of biopsies; derived from four or more linked isoprene units.

dol·i·chol

(dol'i-kol)
Polyisoprenes in which the terminal member is saturated and oxidized to an alcohol, usually phosphorylated, and often glycosylated; found in endoplasmic reticulum, but not in mitochondrial or plasma membranes; urinary levels are elevated in disorders exhibiting abnormal skin, rectal, or brain profiles in electron microscopy of biopsies.

dolichol

special lipid molecule that links oligosaccharide to asparagine residues in proteins via a pyrophosphate bridge; an example of protein glycosylation.
References in periodicals archive ?
Guan believes dolichol profiling could effectively distinguish RP caused by DHDDS mutation from that caused by other mutations.
Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins.
It metabolises to dolichol which participates in the glycosylation of proteins in membranes and in the formation of glycoproteins.
The isoprenoid metabolites (digoxin, dolichol, and ubiquinone), glycoconjugate metabolism, free radical metabolism, and the RBC membrane composition were studied.
Gamma-glutamyltransferase, aspartate and alanine aminotransferases and their ratio, mean cell volume and urinary dolichol in pregnant alcohol abusers.
Lipid peroxidation of microsomal and mitochondrial membranes extracted with n-pentane and reconstituted with ubiquinol, dolichol and cholesterol.
The relationship of dolichol to emotion, behavior, and cognition is due to its role in glycoprotein synthesis (Figure 1).
Dolichol is a carrier of oligosaccharides in glycoprotein metabolism.
In CDG cases, the conversion from polyprenol to dolichol is blocked by a mutation in the SRD5A3 gene.
Gamma-glutamyl transferase, aspartate and alanine aminotransferases and their ratio, mean cell volume and urinary dolichol in pregnant alcohol abusers.
The first mechanism is the entrance of Man and Glc through binding to the lipid carrier dolichol phosphate (Dol-P).