dofetilide


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dofetilide

 [do-fet´ĭ-līd]
an antiarrhythmic that prolongs the duration of the cardiac action potential and the effective refractory period without affecting conduction velocity; used in the treatment of atrial arrhythmias, administered orally.

dofetilide

/do·fet·i·lide/ (do-fet´ĭ-līd) an antiarrhythmic used in the treatment of atrial arrhythmias.

dofetilide

a class III antidysrhythmic.
indications It is used to treat atrial fibrillation and flutter.
contraindications Known hypersensitivity to this drug, digitalis toxicity, aortic stenosis, pulmonary hypertension, QT syndromes, and severe renal disease prohibit its use. It is also contraindicated in children.
adverse effects Serious adverse effects include severe diarrhea, anorexia, angina, premature ventricular contractions, substernal pressure, transient hypertension, and precipitation of angina. Common side effects include syncope, dizziness, nausea, vomiting, hypotension, postural hypotension, and bradycardia.

dofetilide

Tikosyn® Cardiology A selective potassium channel blocking antiarrhythmic used in CHF and left ventricular dysfunction to convert A Fib, prevent its recurrence, and ↓ risk of future hospitalization; it has no effect on mortality Contraindications Succinylcholine-type anesthesia, sick sinus syndrome, seizures Adverse events Torsade de pointes. See Atrial fibrillation.
References in periodicals archive ?
Drug Interactions: Co-administration of cisapride, pimozide, quinidine, dofetilide, levacetylmethadol (levomethadyl), felodipine, oral midazolam, nisoldipine, triazolam, lovastatin, simvastatin, ergot alkaloids such as dihydroergotamine, ergometrine (ergonovine), ergotamine and methylergometrine (methylergonovine) or methadone with ONMEL[TM] is contraindicated.
Table 1--Causes of Long QT Syndrome Congenital Acquired Inherited Metabolic chairnelopathies Roman o-Ward Hypocalcernia, Syndrome hypokalemia, hypomagnesemia Jervell and Lange-Nielsen Syndrome Idiopathic Anti-Arrytbmics Amiodarone, Diospyramide, Dofetilide, ibutilide, Quinidine, Procainamide, Sotalol Antibistarnines Asteinizole, Terfenidine Anti-Infectives Clan thromycin, Erythrornycin, Pentamidine, Sparfi oxcin Anti-Malarial Chioroquine, Halofantrinc Psychotropics Chiorprornazine, Flaloperidol, Thioridazone, SSRIs Heart Disease Left ventricular hvpertrop hy, heart failure, invocardial isehemia
4) Rate control was achieved with beta-blockers with or without digitalis, and rhythm control was maintained by cardioversion, amiodarone, sotalol, or dofetilide.
The most potent QT-prolonging medications are antiarrhythmic agents, particularly amiodarone, dofetilide, quinidine, and sotalol, with quinidine possibly having the most torsadogenic potential.
The newer antiarrhythmics like dofetilide and ibutilide are more potent as well as highly selective for [K.
Proarrhythmia is observed in patients treated with drugs that block the hERG channel, including quinidine, dofetilide, antihistamines, and antibiotics (Bednar et al.
Chemical cardioversion of atrial fibrillation with intravenous dofetilide.
Itraconazole should not be prescribed to patients who are taking cisapride, pimozide, quinidine, dofetilide or levacetylmethadol.
Previously, the seven drugs listed were dofetilide, sotalol, quinidine, thioridazine, moxifloxacin, pimozide, and sparfloxacm.
Contraindication: TIVICAY is contraindicated (1) in patients with previous hypersensitivity reaction to dolutegravir, and (2) in patients receiving dofetilide (antiarrhythmic) due to the potential for increased dofetilide plasma concentrations and the risk for serious and/or life-threatening events.
3 years) were allocated to receive antiarrhythmic drugs, including fle-cainide (Tambocor), propafenone (Ryth-mol), dronedarone (Multaq), amiodarone (Cordarone), dofetilide (Tikosyn), and sotalol (Betapace).