divalproex


Also found in: Dictionary, Encyclopedia, Wikipedia.

divalproex

 [di-val´pro-eks]
an anticonvulsant, used as divalproex sodium, a 1:1 compound of valproate sodium and valproic acid in treatment of migraine, manic episodes of bipolar disorder, and epileptic seizures, particularly absence seizures.

divalproex

/di·val·pro·ex/ (di-val´pro-eks) an anticonvulsant, used as d. sodium, a 1:1 compound of valproate sodium and valproic acid, in the treatment of migraine, manic episodes of bipolar disorder, and epileptic seizures, particularly absence seizures.

divalproex

(dī-văl′prō-ĕks′)
n.
A combination of the drugs valproate and valproic acid, used primarily to treat mania in bipolar disorder and seizures.

carbamazepine

An anticonvulsant used to manage partial seizures and generalised tonic-clonic seizures in children, bipolar disorder and trigeminal neuralgia; in contrast to valproate, carbamazepine is associated with better seizure control, fewer seizures and longer time to first seizure. 

Adverse effects
Dizziness, drowsiness, unsteadiness, nausea, vomiting, myelosuppression (up to 8-fold increase) in aplastic anaemia and agranulocytosis, rash, hair loss.

divalproex

a salt of valproic acid.
References in periodicals archive ?
Leading divalproex sodium market companies like PCAS, Cilag AG CH, Katwijk Chemie BV, Procos S.
that patients with depression responded so well to divalproex," indicates Chang.
The Divalproex Sodium market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status.
Divalproex sodium is marketed as Depakote, Depakote CP, and Depakote ER, and is approved for migraine prophylaxis, manic episodes associated with bipolar disorder, as well as epilepsy.
Divalproex sodium delayed release tablets are indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures, as sole and adjunct therapy for patients with simple and complex absence seizures, for the treatment of the manic episodes associated with bipolar disorders, as well as for prophylaxis of migraine headaches.
The high risk of neural tube defects and other major malformations in babies exposed during the first trimester to valproate sodium and the related products, valproic acid and divalproex sodium, is the focus of an FDA notice.
In the second study, 1,326 patients stabilized following an episode of bipolar I disorder were randomized double-blind to lithium or divalproex plus either quetiapine (Seroquel) or placebo and followed prospectively for up to 104 weeks.
The guidelines, which reviewed all available evidence on migraine prevention, found that among prescription drugs, the seizure drugs divalproex sodium, sodium valproate and topiramate, along with the beta-blockers metoprolol, propranolol and timolol, are effective for migraine prevention and should be offered to people with migraine to reduce the frequency and severity of attacks.
The trial randomized 313 patients with mild-moderate Alzheimer's disease who lacked agitation or psychosis at baseline to either placebo or an extended-release form of divalproex sodium (Depakote ER) at a dose of 10-12 mg/kg per day.
Topiramate (Topamax), a newer drug, has been compared with several other drugs in head-to-head, double-blind studies, including divalproex sodium, nadolol, propranolol, and amitriptyline, she said at the annual meeting of the American College of Physicians.
Twenty-four percent of women on divalproex alone or in combination with other mood stabilizers developed new-onset menstrual abnormalities during treatment.
Table 44: Divalproex ER: sales forecast ($m), 2007-13 114