distal renal tubular acidosis

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Related to distal renal tubular acidosis: proximal renal tubular acidosis

distal renal tubular acidosis (RTA)

an abnormal condition characterized by excessive acid accumulation and bicarbonate excretion. It is caused by the inability of the kidney's distal tubules to secrete hydrogen ions, thus decreasing the excretion of titratable acids and ammonium and increasing the urinary loss of potassium and bicarbonate. The condition may cause hypercalciuria and the formation of kidney stones. Treatment is the same as for renal tubular acidosis. Primary distal RTA occurs mostly in females, adolescents, older children, and young adults. It may occur sporadically or result from hereditary defects. Secondary distal RTA is associated with numerous disorders, such as cirrhosis of the liver, malnutrition, starvation, and various genetic abnormalities. Compare proximal renal tubular acidosis.
References in periodicals archive ?
Hypokalemic paralysis (HP) resulting from distal renal tubular acidosis (dRTA) as the first presenting feature is an example of severe renal involvement preceding the typical sicca syndrome.
Distal renal tubular acidosis is a disease of tubular dysfunction with impaired urine [H.
Urolithiasis and distal renal tubular acidosis preceding primary Sjogren's syndrome: a retrospective study 5-53 years after the presentation of urolithiasis.
ATPase pump in the collecting duct of a patient with hypokalemic distal renal tubular acidosis and Sjogren's syndrome.

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