disseminated lupus erythematosus


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sys·tem·ic lu·pus er·y·the·ma·to·sus (SLE),

[MIM*152700]
an inflammatory connective tissue disease with variable features, frequently including fever, weakness and fatigability, joint pains or arthritis resembling rheumatoid arthritis, diffuse erythematous skin lesions on the face, neck, or upper extremities, with liquefaction degeneration of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with serum antibodies to nuclear protein and sometimes to double-stranded DNA and other substances.

disseminated lupus erythematosus.

sys·tem·ic lu·pus er·y·the·ma·to·sus

(SLE) (sis-tem'ik lū'pŭs ĕr-ith'ĕ-mă-tō'sŭs)
An inflammatory connective tissue disease with variable features including fever; weakness and fatigability; joint pains or arthritis resembling rheumatoid arthritis; diffuse erythematous skin lesions on the face, neck, or upper extremities; lymphadenopathy; pleurisy or pericarditis; glomerular lesions; anemia; hyperglobulinemia; and a positive LE cell test result, with serum antibodies to double-stranded DNA and acidic nuclear protein (Sm).
Synonym(s): disseminated lupus erythematosus.

Patient discussion about disseminated lupus erythematosus

Q. Is a rash a symptom of lupus? My Sister has lupus for several years now. I recently developed a rash on my face. Is this a symptom of lupus? Could I have also been infected with this disease?

A. Lupus has not been proven to be hereditary. Therefore, the fact your sister has lupus shouldn't cause you to beleive you too will develop it. Also a rash is not enough to diagnose lupus. Physicians have to gather information from a variety of sources: past medical history, lab tests and current symptoms. They use a list of 11 criteria to help diagnose SLE. A person needs to satisfy at least 4 out of the 11 criteria before the diagnosis can be pinpointed. Some criteria, such as a biopsy diagnosis of kidney lupus, can carry more weight.

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