disseminated intravascular coagulopathy

disseminated intravascular coagulopathy

Hematology An acquired bleeding diathesis with a generally bad outcome in which the balance between coagulation and fibrinolysis tips toward the former; DIC is characterized by accelerated platelet consumption with coagulation factor depletion–↑ PT, ↑ PTT and stimulation of fibrinolysis–generation of fibrin split products Etiology Severe sepsis–30-65% of DIC is caused by infection, extensive burns, trauma, retained dead fetus, heat stroke, mismatched blood, metastatic CA, leukemia Clinical forms Fast DIC–acute, fulminant, uncompensated consumptive coagulopathy with severe bleeding, and ecchymosis due to abruptio placentae, septic abortion, amniotic fluid embolism, toxemia, malignancy, massive tissue injury–eg burns, surgery, trauma, infections, gram-negative sepsis, meningococcemia, RMSF, incompatible blood; 'fast' DIC requires replacement of deficient or consumed factors Slow DIC Due to chronic compensated illness, with few overt signs of bleeding; clinical picture is painted by thrombosis, microcirculatory ischemia, end-organ infarction, due to acute promyelocytic leukemia, coagulation factor transfusion, CA of pancreas, prostate, lung, stomach, aortic aneurysm, cocaine, IMAOs, giant hemangioma–Kasabach-Merritt syndrome, liver disease, vasculitis, chronic and/or low-grade infections–eg, histoplasmosis, aspergillosis, malaria, obstetrics,–eg, hemolysis, eclampsia, dead fetus, infection, hypoxia, acidosis, respiratory distress; 'slow' DIC may respond to heparinization Lab ↑ PT, aPTT, FDPs, fibrinopeptide A; ↓ fibrinogen, prothrombin, platelets, factor V, factor VIII, antithrombin III, plasminogen, ↓ factors VII, IX, X, XI
References in periodicals archive ?
Additionally, the report provides a 10-year epidemiological forecast for the diagnosed incident cases of sepsis that have comorbid conditions disseminated intravascular coagulopathy (DIC), acute respiratory distress syndrome (ARDS), acute lung injury (ALI), and acute kidney injury (AKI) in the 6MM.
She developed septic shock, disseminated intravascular coagulopathy, and worsening encephalopathy, and she died.
Severe theophylline intoxication, rhabdomyolysis, disseminated intravascular coagulopathy and death: case report.
In patients presenting with thrombocytopenia, diagnosis of ITP is made by exclusion of conditions that may cause thrombocytopenia, which include: drug use (generally heparin, alcohol, quinine/quinidine, sulphonamides), bacterial infections, viral infections (HIV, hepatitis, cytomegalovirus, Epstein-Barr virus), rickettsia infections, mycoplasma infections, lymphoproliferative diseases (chronic lymphocytic leukemia, large granular lymphocytic leukemia, lymphoma), autoimmune diseases (especially systemic lupus erythematosus, antiphospholipid antibody (APA) syndrome), disseminated intravascular coagulopathy, hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, preeclampsia/eclampsia, HELLP syndrome, gestational thrombocytopenia, and hypersplenism.
Disseminated intravascular coagulopathy (DIC) is most frequently seen with acute promyelocytic leukaemia (AML M3), since the promyelocytes contain a high number of these granules.
The patient developed massive intravascular haemolysis, progressive disseminated intravascular coagulopathy (DIC) and cardiovascular collapse.
Postoperatively she remained ventilated on the intensive care unit (ICU) where she developed disseminated intravascular coagulopathy, requiring further transfusions of blood, fresh frozen plasma, platelets and cryoprecipitate.
In a case-control study conducted in the same region, pregnant women with SARS had more severe disease than nonpregnant women and an increased risk for admission to the intensive care unit, development of renal failure, development of disseminated intravascular coagulopathy, and death (26).
Some of the complications of acute fatty liver of pregnancy include diabetes insipidus, disseminated intravascular coagulopathy, spontaneous labor, and postpartum hemorrhage.
One week after initial low-dose chemotherapy, fever, hepatosplenomegaly, bicytopenia, and clinical findings of disseminated intravascular coagulopathy (DIC) developed.
9]/L, and disseminated intravascular coagulopathy developed.

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