Professor John Ioannidis, senior author on the paper, says: "Our comprehensive overview shows that documented reductions in disease-specific mortality
in randomized trials of screening for major diseases are uncommon.
Major Finding: Radical prostatectomy compared with observation produced a 3% absolute reduction in all-cause and disease-specific mortality
The screening benefits from both disease-specific mortality and all-cause mortality data were then compared in terms of number of deaths per 10,000 person-years of observation.
Two trials showed no benefit in disease-specific mortality but a trend in a positive or negative direction in all-cause mortality.
Major Finding: Women with type 2 diabetes in the highest quintile of bran consumption had a 28% lower risk of all-cause mortality and 35% H lower risk of cardiovascular disease-specific mortality
than women in the lowest quintile.
The retrospective study was described as the first to assess disease-specific mortality
risk in the era of prostate-specific antigen (PSA) screening.
One important finding was the observation that the reduction in disease-specific mortality
was greatest among patients younger than 65 years of age.
For limited-stage prostate cancer, there is a lower rate of disease-specific mortality and development of distant metastases with radical prostatectomy compared with watchful.
The watchful waiting group had higher rates of disease-specific mortality (9% vs.