epitope

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Related to discontinuous epitope: antigenic determinant

determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.

ep·i·tope

(ep'i-tōp),
The simplest form of an antigenic determinant on a complex antigenic molecule, which can combine with antibody or T cell receptor.
[epi- + -tope]

epitope

/ep·i·tope/ (ep´ĭ-tōp) an antigenic determinant (see under determinant ) of known structure.

epitope

(ĕp′ĭ-tōp′)
n.
A localized region on the surface of an antigen capable of eliciting an immune response and of combining with a specific antibody to counter that response.

epitope

[ep′itōp]
Etymology: Gk epi + topos, place

epitope

Any site on a biomolecule (antigenic determinant) which can evoke antibody formation. The minimum size of a molecule capable of evoking antibody formation is about 1 kD; if the molecule is smaller, as with haptens, it may evoke an immune response by associating with a carrier protein. Large non-polymeric molecules can have many epitopes. When the van der Waals surfaces of proteins are constructed by X-ray crystallography, epitopic sites appear to require prominently exposed regions—“hills” and “ridges” with surface rigidity. More flexible sites are less antigenic.

epitope

Immunology Any site on a molecule–an antigenic determinant that can evoke antibody formation. See Idiotype, Immunogenicity.

ep·i·tope

(ep'i-tōp)
The simplest form of an antigenic determinant, on a complex antigenic molecule, that can combine with antibody or T-cell receptor.

epitope

An immunologically active discrete site on an ANTIGEN to which an ANTIBODY or a B or T cell receptor actually binds. See also LINEAR EPITOPE and CONFORMATIONAL EPITOPE.

epitope

an antigenic determinant which interacts with an IMMUNOGLOBULIN or T-CELL receptor.

epitope

protein residue at the surface of a microorganism or non-self cell; triggers host immune response

epitope

see antigenic determinant.

continuous epitope
contiguous amino acid sequences in a linear array.
discontinuous epitope
one in which amino acids are in close proximity in the folded protein, but distant when unfolded.