discontinuation

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discontinuation

The act of concluding participation, before completing all protocol-required elements, in a trial by an enrolled subject. Subject discontinuation does not necessarily imply exclusion of the subject’s data from analysis.

Categories of discontinuation
• Dropout—Discontinuation of a trial by a subject or the discontinued subject him- or herself.
• Investigator initiated discontinuation (e.g., for cause).
• Loss to follow-up—Cessation of participation without notice or action by the subject.
• Sponsor initiated.
References in periodicals archive ?
A 1989 simulation analysis illustrated the importance of high contraceptive discontinuation to contraceptive prevalence.
Three outcome variables were used in this analysis: current use of a modern contraceptive method, method mix and contraceptive discontinuation resulting in unmet need.
This index, however, is not useful in answering the following question: What is the projected contribution of current users of modern methods to unmet need in the future if these users experience the current high contraceptive discontinuation rates?
Four variables were considered to explain country-level variations in the relevant discontinuation index: the number of available methods, the type or composition of available methods, the country's Human Development Index (HDI) and its region.
We ran several simple and multiple regression analysis models to identify associations between the explanatory or independent variables of method access, method composition, region and HDI index and the outcome or dependent variables of contraceptive prevalence, method mix and the projected contribution of contraceptive discontinuation to unmet need in the future.
The relevant discontinuation rate (past users with unmet need as a percentage of ever-users) was estimated to be 19% for all countries combined.
RESULTS: The proportion of births reported as intended following contraceptive failure ranged from 16% in Bangladesh to 54% in Kazakhstan, and the proportion reported as intended following discontinuation for reasons other than a desire for pregnancy ranged from 37% in Kenya to 51% in Kazakhstan.
CONCLUSION: These findings suggest that underlying variation in the motivation to avoid pregnancy is an important factor in contraceptive discontinuation.
1), (2) Analyses of survey data have demonstrated that contraceptive discontinuation is common.
High rates of contraceptive discontinuation for reasons other than the desire for pregnancy are a public health concern because of their association with negative reproductive health outcomes.
3), (14), (15) Knowledge of the factors that may lead to contraceptive discontinuation remains incomplete, and a better understanding is hampered by the lack of a comprehensive framework that acknowledges the multiple and complex reasons that influence the decision to switch methods or stop using one altogether.
Established in 1981, Rochester specializes in aiding customers after the discontinuation of products.