discontinuation


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discontinuation

The act of concluding participation, before completing all protocol-required elements, in a trial by an enrolled subject. Subject discontinuation does not necessarily imply exclusion of the subject’s data from analysis.

Categories of discontinuation
• Dropout—Discontinuation of a trial by a subject or the discontinued subject him- or herself.
• Investigator initiated discontinuation (e.g., for cause).
• Loss to follow-up—Cessation of participation without notice or action by the subject.
• Sponsor initiated.
References in periodicals archive ?
When medically stable for transfer, patients who have failed ventilator discontinuation attempts in the intensive care unit should be transferred to those facilities that have demonstrated success and safety in accomplishing ventilator discontinuation.
In contrast, reported failure is the most common cause of discontinuation of the two traditional methods, cited by 17% of those using periodic abstinence, and 15% of those using withdrawal.
For the multivariate analysis, we created a summary measure that distinguished between women who mentioned side effects as a reason for discontinuation (whether it was their main reason or not) and those who did not cite this as a reason.
While this will not entirely prevent discontinuation symptoms from occurring, it may lesson the symptoms' severity.
Both draft letters make essentially the same points in response to Rosenbaum and Zajecka: (1) discontinuation symptoms have been reported with all SSRIs; (2) discontinuation symptoms with SSRIs are relatively mild and transient; (3) symptoms are less severe than those associated with discontinuation of tricyclic antidepressants; (4) incidence of adverse effects after abrupt discontinuation of paroxetine has been very low; and (5) the short half-life of paroxetine is a benefit when flexibility is desired in situations where switching or discontinuation of a medication is required.
This shows that these disturbances are important reasons for discontinuation any time they occur," says Dr.
5 months after discontinuation of the BT test were determined by reviewing patient medical records.
This study involved treatment discontinuation (treatment duration ranged from 12 to 40 months), i.
Earlier in the day, an LDP panel okayed the discontinuation of 211 public works projects by the Construction Ministry, the Transport Ministry and the Ministry of Agriculture, Forestry and Fisheries.
In a study published in the Journal of Managed Care Pharmacy, discontinuation of alendronate therapy within the first six months of treatment occurred in 35 percent of patients, most often because of gastrointestinal complaints (51.
The applicant appealed the attorney fee decision and the appeals court affirmed, finding that the applicant was not entitled to attorney fees absent evidence that the discontinuation of psychological testing affected his relationship with the county at the time the judgment was rendered, or that he directly benefited from the injunction.
As expected, our aggregate sales were down from the previous year due to the discontinuation of marginally profitable personal computers and home office equipment," said Ronald Unkefer, founder, chairman and chief executive.