directed differentiation

directed differentiation

The use of growth factors to stimulate stem cells to specialize into specific adult cells.
References in periodicals archive ?
More directed differentiation of ESCs to the neuronal lineage occurred upon addition of 0.
This system provides a complete solution for directed differentiation of disease-specific or patient-specific human inducible pluripotent stem (hiPS) cells to hepatocytes by combining a standardized protocol and optimized, ready-to-use media and coating reagents.
TEHRAN (FNA)- Age-related macular degeneration could be treated by transplanting photoreceptors produced by the directed differentiation of stem cells, new research suggests.
The goal of Nishant's project during his freshman and sophomore year was to identify genes that mark different stages in the process of directed differentiation.
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.
Singapore, Mar 1, 2012 - (ACN Newswire) - A*STAR scientists have for the first time, identified that precise regulation of polyamine levels is critical for embryonic stem cell (ESC) self-renewal - the ability of ESCs to divide indefinitely - and directed differentiation.
Specific topics include isolation of adult mouse stem keratinocytes using magnetic cell sorting, growth and stratification of epithelial cells in minimal culture conditions, establishment of spontaneously immortalized keratinocyte lines from wild-type and mutant mice, directed differentiation of human embryonic stem cells to epidermal progenitors, expression and analysis of exogenous proteins in epidermal sells, and gene expression profiling of mouse epidermal keratinocytes.
Having learnt some lessons from SCNT (cloning), we need to be very cautious in generating stem cells by directed differentiation (IPS) or de-differentiation for cell therapy to treat diseases.
A significant challenge faced by developers of such clinical approaches is that a substantial expansion in stem cell number needs to occur that is coupled with a directed differentiation of those stem cells to appropriate cell types.
16-18) Having established appropriate growth conditions for the directed differentiation of adult stem cells toward hair cells, Li et al attempted to determine if embryonic stem cells could also differentiate into hair-cell-like cells.
BioTime's HyStem([R])hydrogels are dynamic products that have the demonstrated ability to support the growth and directed differentiation of stem cells, and are designed as injectable, resorbable matrices for tissue engineering, regenerative medicine, and for research applications involving the laboratory culture of human cells.
The product combines pancreatic progenitor cells called PEC-01, produced by a directed differentiation process, encapsulated with a semi-permeable device called the Encaptra Drug Delivery System, both are proprietary technologies.