direct antiglobulin test

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Related to direct antiglobulin test: Coombs test, Indirect Antiglobulin Test

direct antiglobulin test

Direct Coombs test Immunology A test to detect immune hemolysis caused by binding of Ig and/or complement components to RBCs after sensitization to an antigen–eg Rh factor–on the RBC surface; a DAT helps differentiate autoimmune and 2º immune hemolytic anemia, which can be drug-induced or associated with underlying disease such as lymphoma. See Indirect antiglobulin test.

direct antiglobulin test

Abbreviation: DAT
A laboratory test for the presence of complement or an antibody that is bound to a patient's red blood cells (RBCs). The test is used in patients with autoimmune hemolytic anemia, hemolytic disease of the newborn, and transfusion reactions. After the patient's RBCs are washed to remove unbound antibodies, they are mixed with antihuman globulin serum containing polyvalent antibodies that bind with the antibody or complement on the RBCs and cause them to agglutinate (clump). Monoclonal antibodies can be used to identify the specific class of antibody or complement component causing RBC destruction. See: Coombs' test


without intervening steps.

direct antiglobulin test
see direct coombs test.
direct capture ELISA mastitis test
measures polymorphonuclear antigens in milk sample as an indication of elevated milk cell counts and therefore presence of mastitis.
direct contact
see direct contact.
direct costs
see variable costs.
direct effect
the effect of one variable on another without passing through a third variable.
direct immunofluorescence testing
see fluorescence microscopy.
direct oxidative pathway
see pentose phosphate pathway.
direct relationship
see direct relationship.
References in periodicals archive ?
The result of the direct antiglobulin test (DAT) [3] was 2+ (moderately positive) for IgG, and the eluate was nonreactive.
Results of the ABO, Rh, antibody screen and direct antiglobulin test (DAT) should be standardized and entered into the blanks provided.

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