direct adverse effects

direct adverse effects,

n.pl unfavorable outcomes as a direct result of treatment. Includes toxic effects and side effects of various duration.
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Importantly, however, the authors have inappropriately interpreted the lack of an effect of the MTHFR polymorphism on cardiovascular risk as a lack of direct adverse effects of homocysteine on the cardiovascular system.
Absent any efforts to mitigate the expected loss of revenues, these changes are expected to have an annual direct adverse effect (based on the Company's current calls and SMS data) of approximately NIS 420 million on the Company's EBITDA and approximately NIS 320 million on the Company's net income, for the first reduction.
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