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Apo-Dipyridamole FC (CA), Apo-Dipyridamole SC (CA), Persantin (UK), Persantine
Pharmacologic class: Platelet adhesion inhibitor
Therapeutic class: Antiplatelet agent, diagnostic agent (coronary vasodilator)
Pregnancy risk category B
Unclear. May reduce platelet aggregation by inhibiting phosphodiesterase, adenosine uptake, or formation of thromboxane A2.
Tablets: 25 mg, 50 mg, 75 mg
⊘Indications and dosages
➣ To prevent thromboembolism in patients with prosthetic heart valves
Adults: 75 to 100 mg P.O. q.i.d.
• Prevention of myocardial reinfarction (given with aspirin)
• Thrombotic thrombocytopenia purpura
• Hypersensitivity to drug
Use cautiously in:
• hypotension, hepatic insufficiency, severe coronary artery disease
• pregnant or breastfeeding patients
• children younger than age 12 (safety not established).
• Know that drug is usually given with warfarin when used to prevent thromboembolism.
• Give with a full glass of water at least 1 hour before or 2 hours after meals. If gastric distress occurs, give with food.
CNS: dizziness, headache
GI: abdominal distress
Hepatic: hepatic failure
Drug-drug.Adenosine: increased adenosine plasma level and CV effects
Cholinesterase inhibitors: counteracts activity of cholinesterase inhibitors
Drug-diagnostic tests.Hepatic enzymes: increased levels
Drug-behaviors.Alcohol use: increased risk of hypotension
• Monitor for therapeutic efficacy, including improved exercise tolerance and decreased need for nitrates.
• Assess platelet and coagulation studies regularly.
• Monitor ECG and vital signs, especially blood pressure.
• Monitor hepatic function tests regularly.
• Advise patient to take drug 1 hour before or 2 hours after meals for best absorption.
☞ Instruct patient to immediately report unusual tiredness, chest pain or other cardiac symptoms, upper right abdominal pain, yellowing of skin or eyes, or dark urine.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.
dipyridamole/di·py·rid·a·mole/ (di″pĭ-rid´ah-mōl) a platelet inhibitor and coronary vasodilator used to prevent thromboembolism associated with mechanical heart valves, to treat transient ischemic attacks, and as an adjunct in preventing myocardial reinfarction and in myocardial perfusion imaging.
dipyridamoleA drug used to reduce platelet stickiness and thus the risk of STROKE in people having TRANSIENT ISCHAEMIC ATTACKS. Aspirin is more effective, but sometimes cannot be safely taken. A brand name is Persantin.
antiplatelet therapyagents that reduce platelet aggregation and inhibit arterial thrombus formation in an area of the circulation where other anticoagulants have reduced effect; e.g. low-dose aspirin (75 mg daily), clopidogrel (± low-dose aspirin), dipyridamole (used to prevent thromboembolism in patients with prosthetic heart valves), abciximab, eptifibatide and tirofiban
n brand name: Persantine;
drug class: platelet aggregation inhibitor;
action: specific action unclear; inhibits ability of platelets to aggregate;
uses: prevention of transient ischemic attacks (TIA), inhibition of platelet aggregation to prevent myocardial reinfarction, prevention of coronary bypass graft occlusion with aspirin.