diphtheria toxoid


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Related to diphtheria toxoid: diphtheria antitoxin, tetanus toxoid

toxoid

 [tok´soid]
a toxin treated by heat or chemical agent to destroy its deleterious properties without destroying its ability to combine with or stimulate the formation of antitoxin.
diphtheria toxoid a sterile preparation of formaldehyde-treated products of the growth of Corynebacterium diphtheriae, used as an active immunizing agent, generally in mixtures with tetanus toxoid and pertussis vaccine (DTP) or with tetanus toxoid alone (DT for pediatric use and Td, which contains less diphtheria toxoid, for adult use).
tetanus toxoid a sterile preparation of formaldehyde-treated products of the growth of Clostridium tetani, used as an active immunizing agent, either in mixtures with diphtheria toxoid and pertussis vaccine (DTP, DT, Td) or by itself (T).

diphtheria toxoid

Diphtheria toxin altered so that it cannot cause disease but is still able to stimulate the production of antibodies for active immunization. It is used in diphtheria-pertussis-tetanus vaccine (DTaP).
See also: toxoid
References in periodicals archive ?
MassBiologics' Td may be used for post-exposure diphtheria prophylaxis in persons 7 years of age and older who have not completed primary vaccination, whose vaccination status is unknown, or who have not been vaccinated with diphtheria toxoid within the previous 5 years.
The safety of GARDASIL when administered concomitantly with Menactra [Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine] and Adacel [Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Tdap)] was evaluated in a randomized study of 1040 boys and girls with a mean age of 12.
When Moscow asked the WHO and the United States for help, researchers found that immunization there was by "natural exposure" (to the disease) or through vaccination with a "weak" diphtheria toxoid made during the 1950s.
Hypersensitivity to any component, including diphtheria toxoid, is a contraindication to its use.
Still, in our previous study, a doubling of the PCB exposure at 18 months was associated with a decrease in the concomitant antibody response to the diphtheria toxoid by 24%, and the decrease in the tetanus toxoid antibody at age 7 years was 16% for each doubling of the prenatal exposure level (Heilmann et al.
She reported on 314 pregnant women presenting to an academic perinatal center between March and June 2011 who answered an anonymous, multiple-choice questionnaire regarding their knowledge and opinions on vaccination in general, and Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis adsorbed) specifically.
5 ml dose of the combined DTaP-IPV//PRP~T vaccine (Pentaxim[TM], Sanofi Pasteur, France, batch number Z2044-1 contained [greater than or equal to]30 IU diphtheria toxoid, >40 IU tetanus toxoid, 25 [micro]g pertussis toxoid, 25 [micro]g filamentous haemagglutinin, 40 U inactivated type 1 poliovirus, D antigen, 8 U inactivated type 2 poliovirus, D antigen, 32 U inactivated type 3 poliovirus, D antigen, and 10 [micro]g H.
Guillain-Barre syndrome after tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine: a case report.
Updated Recommendations for Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine (Tdap) in Pregnant Women.
Although all close contacts had completed the series of diphtheria toxoid vaccinations, they were all given postexposure prophylaxis with erythromycin.
Preventing tetanus, diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine recommendations of the Advisory Committee on Immunization Practices (ACIP) and recommendation of ACIP, supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), for use of Tdap among health-care personnel.
Food and Drug Administration (FDA) has licensed Menactra(TM) (Meningococcal [Groups A, C, Y and W-135] Polysaccharide Diphtheria Toxoid Conjugate Vaccine) for protection against meningococcal disease in adolescents and adults aged 11-55 years.

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