diphtheria antitoxin

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Related to diphtheria antitoxin: diphtheria toxoid


a particular kind of antibody produced in the body in response to the presence of a toxin; see also immunity. adj., adj an´titoxic.
botulism antitoxin an equine antitoxin against the toxins produced by the types A and B and/ or E strains of Clostridium botulinum; administered intravenously in the postexposure prophylaxis and treatment of botulism, other than infant botulism. Generally trivalent (ABE) antitoxin is used.
diphtheria antitoxin equine antitoxin from horses immunized against diphtheria toxin or the toxoid; administered intramuscularly or intravenously in the treatment of suspected cases of diphtheria.
equine antitoxin an antitoxin derived from the blood of healthy horses immunized against a specific bacterial toxin.
tetanus antitoxin equine antitoxin from horses that have been immunized against tetanus toxin or toxoid; used for the passive prevention and treatment of tetanus. It is rarely used, tetanus immune globulin being preferred.

diph·the·ri·a an·ti·tox·in

antitoxin specific for the toxin of Corynebacterium diphtheriae.

diphtheria antitoxin

Etymology: Gk, diphtheria, leather membrane, anti, against, toxikon, poison
an antitoxin prepared by immunizing horses with diphtheria toxoid and extracting serum from the animal. The serum is standardized for strength and quality.

diphtheria antitoxin

A preparation of horse antibodies to diphtheria used exclusively to treat suspected cases of diphtheria in which the risk of the disease exceeds the risk of the injection. The drug is not used as a diphtheria preventive because of the severe risk of hypersensitivity. The drug is on the WHO official list.
References in periodicals archive ?
Use of diphtheria antitoxin (DAT) for suspected diphtheria cases [cited 2015 Aug 19].
Suspected cases should be reported to local public health authorities; diphtheria antitoxin is available from CDC's Child Vaccine Preventable Disease Branch, Epidemiology and Surveillance Division, National Immunization Program, telephone (404) 639-8255, Monday-Friday, 8:00 a.
Treatment comprised 80,000 IU of diphtheria antitoxin and a course of parenteral penicillin.
The level of diphtheria antitoxin antibodies was measured with a toxin-binding inhibition assay (8).
Linear regression analysis was used to study the persistence of diphtheria antitoxin antibodies after full immunization in the national immunization program.
The toxin inhibition test used to measure diphtheria antitoxin concentrations shows good correlation with the in vitro neutralization test in Vero cells, but is faster, simpler, and combines the measurement of diphtheria and tetanus antitoxin antibodies (8,9).
The sharp increase in the percentage of persons older than 44 years with no protective diphtheria antitoxin levels is consistent with findings of other studies (4,11,12,14-19).
3%) who received their last vaccination approximately 25 years ago had a diphtheria antitoxin level of less than 0.
Only sporadic cases and no outbreaks have occurred in other European countries where gaps have been found in the diphtheria antitoxin levels of adults.
In conclusion, a substantial percentage of adults born before the introduction of the immunization program has low diphtheria antitoxin levels.

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