diphthamide


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diphthamide

an amino acid residue formed by post-translational modification of histidine. There is ADP-ribosylation of elongation factor 2 (EF2) protein; the mode of action of diphtheria toxin whereby translation of mRNA is blocked.
References in periodicals archive ?
In contrast to bacterial EF2, eEF2 and EF2 from archaea contain a unique and strictly conserved posttranslationally modified histidine referred to as diphthamide (9).
The weaker signal with the immobilized eEF2 may result from decreased accessibility of DT to diphthamide.
Identified protein sequence SSP3544 Loin 018840 Actin, cytoplasmic 1 AVFPSIVGRPR (Beta-actin) SSP5509 Loin Q8RFX6 Probable D-serine dehydratase SSP5605 Loin Q4WPF7 Diphthamide biosynthesis protein 4 SSP3121 Plate Q29095 Prostaglandin-H2 D-isomerase precursor transmembrane emp24 SSP2006 Round P49020 Domain containing RFFEVR protein 2 precursor SSP2323 Round P35285 Ras-related protein RQPSEPK Rab-22A SSP5213 Round Q9PDLO Chorismate synthase SSP5214 Round Q5HT90 Imidazole glycerol phosphate synthase subunit hisH 1 SSP9307 Round PO2587 Troponin C, skeletal Spot Theor.

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