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diphosphonate

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diphosphonate /di·phos·pho·nate/ (di-fos´fŏ-nāt)
1. a salt, ester, or anion of a dimer of phosphonic acid, structurally similar to pyrophosphate but more stable.
2. any of a group of such compounds, having affinity for sites of osteoid mineralization and used as sodium salts to inhibit bone resorption as well as complexed with technetium Tc 99m for bone imaging.

diphosphonate
[difos′fonāt]
any of a group of related phosphorus-containing compounds that are structurally similar to pyrophosphate but have enhanced stability to enzymatic and chemical hydrolysis and have affinity for sites of osteoid mineralization. They are used as sodium salts to inhibit bone resorption and are complexed with technetium Tc 99m for bone imaging. The group includes alendronate, etidronate, and pamidronate. Also called bisphosphonate.

diphosphonate [di-fos´fo-nāt]
any of a group of related phosphorus-containing compounds that are structurally similar to pyrophosphate but have enhanced stability to enzymatic and chemical hydrolysis and have affinity for sites of osteoid mineralization. They are used as sodium salts to inhibit bone resorption as well as complexed with technetium Tc 99m for bone imaging. The group includes alendronate, etidronate, and pamidronate. Called also bisphosphonate.

diphosphonate


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3-5) Several radiopharmaceuticals have been shown to have avid uptake by MFH, including Tc-99m methylene diphosphonate (MDP), gallium-67 (Ga-67) citrate, Tc-99m sestamibi, Tc-99m hexamethylpropyleneamine oxime (HMPAO), indium-111(In-111)-labeled leukocytes, Tc-99m sulfur colloid, and Tc-99m-labeled antifibrin monoclonal antibody.
 
 
 
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