diphosphonate


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diphosphonate

 [di-fos´fo-nāt]
any of a group of related phosphorus-containing compounds that are structurally similar to pyrophosphate but have enhanced stability to enzymatic and chemical hydrolysis and have affinity for sites of osteoid mineralization. They are used as sodium salts to inhibit bone resorption as well as complexed with technetium Tc 99m for bone imaging. The group includes alendronate, etidronate, and pamidronate. Called also bisphosphonate.

diphosphonate

/di·phos·pho·nate/ (di-fos´fŏ-nāt)
1. a salt, ester, or anion of a dimer of phosphonic acid, structurally similar to pyrophosphate but more stable.
2. any of a group of such compounds, having affinity for sites of osteoid mineralization and used as sodium salts to inhibit bone resorption as well as complexed with technetium Tc 99m for bone imaging.

diphosphonate

(dī′fŏs′fə-nāt′)
n.
Variant of bisphosphonate.

diphosphonate

[difos′fonāt]
any of a group of related phosphorus-containing compounds that are structurally similar to pyrophosphate but have enhanced stability to enzymatic and chemical hydrolysis and have affinity for sites of osteoid mineralization. They are used as sodium salts to inhibit bone resorption and are complexed with technetium Tc 99m for bone imaging. The group includes alendronate, etidronate, and pamidronate. Also called bisphosphonate.

bisphosphonate

Any of a family of drugs with two phosphonate (PO3) groups, which inhibit enzymes that break down pyrophosphate. Bisphosphonates include etidronate and clodronate (first-generation agents), and pamidronate disodium (a second-generation bisphosphonate), which inhibits bone resorption at doses that do not affect bone mineralisation. Bisphosphonates are potent inhibitors of bone resorption that bind tightly to the hydroxyapatite crystals, and have therapeutic potential in osteoporosis and in advanced (stage-III) multiple myeloma and Paget’s disease of bone.

Indications
Treat and prevent osteoporosis, osteolysis due to metastatic breast and prostate cancer, multiple myeloma, Paget's disease of bone, fibrous dysplasia, Gaucher's disease, etc.

Adverse effect
Upset stomach, gastritis, oesophageal erosions; long-term effects include femoral fractures and an increased risk of oesophageal cancer.

Agents
Etidronate, clodronate, tiludronate.

diphosphonate

References in periodicals archive ?
Radionuclide diagnosis of vertebral osteomyelitis: lndium-111-leukocyte and technetium-99m-methylene diphosphonate bone scintigraphy.
10) Another notable test is the technetium Tc 99m methylene diphosphonate bone scan, which uses a radioactive intravenous imaging agent to locate the sites of possible lesions.
It uses diphosphonate radiotracers marked with technetium-99 metastable isotope ([sup.
The lesions can be detected even earlier by bone scan using Gallium 67 citrate and Tc-99 diphosphonate agents rather than plain radiographs.
Radioisotope Tc99m methylene diphosphonate bone scans have been used to identify occult areas but it seemed ineffective diagnostic tool being poor in resolution.
Detection of cardiac calcinosis in hemodialysis patients by whole-body scintigraphy with 99m-technetium methylene diphosphonate.
Imaging included Technetium-99m methylene diphosphonate ([Tc.
Bone scan demonstrated an increased uptake of a technetium-99m-methylene diphosphonate (99mTc-MDP) in the left shoulder, but no areas of osteonecrosis were detected elsewhere in the skeleton.
Inhibition of post-extract ion alveolar ridge resorption in rats by dichloromethane diphosphonate.