diphosphonate


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diphosphonate

 [di-fos´fo-nāt]
any of a group of related phosphorus-containing compounds that are structurally similar to pyrophosphate but have enhanced stability to enzymatic and chemical hydrolysis and have affinity for sites of osteoid mineralization. They are used as sodium salts to inhibit bone resorption as well as complexed with technetium Tc 99m for bone imaging. The group includes alendronate, etidronate, and pamidronate. Called also bisphosphonate.

diphosphonate

/di·phos·pho·nate/ (di-fos´fŏ-nāt)
1. a salt, ester, or anion of a dimer of phosphonic acid, structurally similar to pyrophosphate but more stable.
2. any of a group of such compounds, having affinity for sites of osteoid mineralization and used as sodium salts to inhibit bone resorption as well as complexed with technetium Tc 99m for bone imaging.

diphosphonate

(dī′fŏs′fə-nāt′)
n.
Variant of bisphosphonate.

diphosphonate

[difos′fonāt]
any of a group of related phosphorus-containing compounds that are structurally similar to pyrophosphate but have enhanced stability to enzymatic and chemical hydrolysis and have affinity for sites of osteoid mineralization. They are used as sodium salts to inhibit bone resorption and are complexed with technetium Tc 99m for bone imaging. The group includes alendronate, etidronate, and pamidronate. Also called bisphosphonate.

bisphosphonate

Any of a family of drugs with two phosphonate (PO3) groups, which inhibit enzymes that break down pyrophosphate. Bisphosphonates include etidronate and clodronate (first-generation agents), and pamidronate disodium (a second-generation bisphosphonate), which inhibits bone resorption at doses that do not affect bone mineralisation. Bisphosphonates are potent inhibitors of bone resorption that bind tightly to the hydroxyapatite crystals, and have therapeutic potential in osteoporosis and in advanced (stage-III) multiple myeloma and Paget’s disease of bone.

Indications
Treat and prevent osteoporosis, osteolysis due to metastatic breast and prostate cancer, multiple myeloma, Paget's disease of bone, fibrous dysplasia, Gaucher's disease, etc.

Adverse effect
Upset stomach, gastritis, oesophageal erosions; long-term effects include femoral fractures and an increased risk of oesophageal cancer.

Agents
Etidronate, clodronate, tiludronate.

diphosphonate

References in periodicals archive ?
99m]Tc methylene diphosphonate is exquisitely sensitive because the radiotracer accumulates at sites of osteoblastic activity.
Atypical Femur Fractures Associated With Diphosphonate Use
16) Several studies have reported improved detection of both benign and malignant bone lesions with NaF PET compared to technetium methylene diphosphonate (TcMDP), although most of these were performed on adults.
Technetium-99m methylene diphosphonate (Tc-99m MDP) three-phase bone scintigraphy (TPBS) confirmed the clinical diagnosis of bilateral CRPS by detecting the mild or intense increased activity uptake in a dynamic, early blood pool, especially in delayed static images (Figure 3).
Tenebaum F, Schlumberga M, Bonnin F, et al: Usefulness of technetium-99m hydroxy methylene diphosphonate scans in localizing bone metastases of differentiated thyroid carcinoma.
99m]Technetium methylene diphosphonate bone scan may demonstrate the distribution and extent of gouty arthritis.
Losbona et al have suggested that 99mTc-methylene diphosphonate (99mTc-MDP) imaging is helpful in diagnosing early acute osteomyelitis.
Technetium-99m-labeled methylene diphosphonate ([Tc-99] MDP) bone scan is another test with high sensitivity (90%) but low specificity (78%) in the diagnosis of vertebral osteomyelitis.
Nuclear medicine detection of osteomyelitis is performed utilizing Technetium-99m methylene diphosphonate, either alone or in conjunction with Gallium-67 or Indium-111 labeled leukocytes.
6) There is little evidence to support the use of bone scintigraphy with Technetium-99 methylene diphosphonate ([sup.
A Tc-99m-methylene diphosphonate (MDP) bone scan revealed diffuse metastatic visceral calcifications on the lungs, myocardium and stomach (Figs 3a and b).
Duration of the effects of oral diphosphonate therapy in Paget's disease of bone.