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diphosphonate |
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diphosphonate /di·phos·pho·nate/ (di-fos´fo-nat) 1. a salt, ester, or anion of a dimer of phosphonic acid, structurally similar to pyrophosphate but more stable. 2. any of a group of such compounds, having affinity for sites of osteoid mineralization and used as sodium salts to inhibit bone resorption as well as complexed with technetium Tc 99m for bone imaging. diphosphonate see bisphosphonates. |
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Technetium-99m-labeled methylene diphosphonate ([Tc-99] MDP) bone scan is another test with high sensitivity (90%) but low specificity (78%) in the diagnosis of vertebral osteomyelitis. a diphosphonate compound used for treatment of osteitis deformans, heterotopic ossification, and neoplasm-associated hypercalcemia, usually as the disodium salt. a diphosphonate compound used for treatment of osteitis deformans, heterotopic ossification, and neoplasm-associated hypercalcemia, usually as the disodium salt. |
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